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On the occurrence, behaviour, and fate of naphthenic acid fraction compounds in aquatic environments.
Sci Total Environ
January 2025
Department of Civil, Geological and Environmental Engineering, University of Saskatchewan, 57 Campus Dr, Saskatoon, Saskatchewan S7N 5A9, Canada; University of Lethbridge, Office of the Vice President (Research), Lethbridge, Alberta, Canada. Electronic address:
Naphthenic acids and naphthenic acid fraction compounds (NAFCs) are associated with production of unconventional petroleum resources, especially the Athabasca Oil Sands of Alberta, Canada. This complex mixture of acidic organic compounds is toxic to a variety of taxa, and so represents an important environmental management challenge. Thus, there is clear motivation to better understand the occurrence and characteristics of NAFCs in aquatic environments, their chemical behaviour, and environmental fate.
View Article and Find Full Text PDFA Phase I Study of Romidepsin in Combination With Gemcitabine, Oxaliplatin, and Dexamethasone in Patients With Relapsed or Refractory Aggressive Lymphomas Enriched for T-Cell Lymphomas.
Clin Lymphoma Myeloma Leuk
December 2024
Division of Medical Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO. Electronic address:
Introduction: Histone deacetylase inhibitors (HDACi) and combination chemotherapy are independently used to treat relapsed/refractory (R/R) lymphoma. In vitro studies suggest that the addition of HDACi to platinum-based chemotherapy is synergistic.
Patients And Methods: We conducted a phase I study of romidepsin, gemcitabine, oxaliplatin and dexamethasone (Romi-GemOxD) in R/R aggressive lymphomas with an expansion cohort in T-cell lymphomas.
AbstractTheoretical studies from diverse areas of population biology have shown that demographic stochasticity can substantially impact evolutionary dynamics in finite populations, including scenarios where traits that are disfavored by natural selection can nevertheless increase in frequency through the course of evolution. Here, we analytically describe the eco-evolutionary dynamics of finite populations from demographic first principles. We investigate how noise-induced effects can alter the evolutionary fate of populations in which total population size may vary stochastically over time.
View Article and Find Full Text PDFAntibiotic resistance partitioning during on-farm manure separation and high temperature rotary drum composting.
J Environ Sci (China)
June 2025
Department of Environmental Science, University of Maryland, College Park, MD 20742, USA. Electronic address:
Manure application as fertilizer can increase environmental exposure risk, as antibiotics, antibiotic resistance bacteria (ARB), and antibiotic resistant genes (ARGs) can be transmitted to agricultural fields, and adjacent natural systems. Understanding how specific antibiotics and ARGs respond within different manure fractions during on-farm management is limited. The study objective was to conduct a mass flow analysis determining the fate of antibiotic resistance factors (antibiotics, ARGs, and ARB) through solid-liquid separation, with the solid fraction continuing through a bedding recovery unit (BRU) via high temperature rotary composting for use of the manure solids as dairy cow bedding.
View Article and Find Full Text PDFDisposable face masks into aquatic media: Chemical and biological testing of the released compounds during the leaching process.
Environ Pollut
December 2024
Section of Animal Biology, Department of Biology, University of Patras, GR-26500, Patras, Greece. Electronic address:
The present study investigated the fate, and the biological effects posed by the presence of Disposable Face Masks (DFMs) into fresh- and saltwater media, using both chemical and biological testing. To this end, slightly fragmented DFMs were maintained in tanks with artificial sea water (ASW) or dHO (DFMASW and DFMdHO, respectively) for a period of 20 days (under continuous agitation, oxygen supply, and light/dark ration 1:1) to simulate both fresh- and saltwater natural conditions. Thereafter, DFMs leaching substances were determined, before proceeding to biological testing with the use of the marine bacterium Aliivibrio fischeri (Bioluminescence Inhibition assay), the fresh- and saltwater algal species Chlorococcum sp.
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