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Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice.
PLoS One
January 2025
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Atherosclerosis is a progressive arterial disease arising from imbalanced lipid metabolism and a maladaptive immune response. The lymphatic system ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells to draining lymph nodes, thereby potentially affecting atherogenesis. Endothelial cell-specific deletion of Pannexin1 (Panx1) in apolipoprotein E-deficient (Apoe-/-) mice increased atherosclerosis, suggesting a protective role for Panx1 channels in arterial endothelial function.
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- The study focuses on understanding how different types of exercise and metformin impact vascular health in diabetic rats, particularly looking at oxidative stress and inflammation.
- The research involved inducing diabetes in rats and subjecting them to various treatments, revealing that all treatments improved crucial biochemical markers related to diabetes.
- Notably, combining exercise with metformin showed greater benefits, especially with interval training, suggesting a dual approach could enhance therapy for diabetes-related cardiovascular issues.
Background: TPM3 (tropomyosin 3) is an actin-binding protein in vascular smooth muscle cells, where posttranslational modifications critically regulate its actin affinity, influencing cardiovascular function. Emerging evidence suggests that Khib (2-hydroxyisobutyrylation) plays a significant role in the cardiovascular system. Histone deacetylase 3 (HDAC3) serves as an "eraser" of Khib marks.
View Article and Find Full Text PDFDeciphering hematopoietic stem cell development: key signaling pathways and mechanisms.
Front Cell Dev Biol
December 2024
Microscopic and Developmental Anatomy, Tokyo Women's Medical University, Tokyo, Japan.
Most blood cells derive from hematopoietic stem cells (HSCs), originating from endothelial cells. The induction of HSCs from endothelial cells occurs during mid-gestation, and research has revealed multiple steps in this induction process. Hemogenic endothelial cells emerge within the endothelium, transition to hematopoietic cells (pre-HSCs), and subsequently mature into functional HSCs.
View Article and Find Full Text PDF[Protection of vasodilatory function in rats with post-infarction heart failure by salvianolic acid B via modulating Piezo1 channel].
Zhongguo Zhong Yao Za Zhi
October 2024
Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Chinese Materia Pharmacology, National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases Beijing 100091, China Heilongjiang University of Chinese Medicine Harbin 150040, China.
To explore the regulation of vasodilatory function in rats with post-infarction heart failure by salvianolic acid B(Sal-B) based on the mechanosensitive ion channel, namely Piezo1. A post-infarction heart failure model of rats was prepared by ligation of the left anterior descending coronary artery. After successful modeling, the rats were randomly divided into the model group, Sal-B group(0.
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