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Unveiling the Intricate Link Between Anaerobe Niche and Alzheimer Disease Pathogenesis.
J Infect Dis
September 2024
Department of Pathology and Laboratory Medicine, Medical University of South Carolina.
Article Synopsis
- * The review focuses on anaerobic environments near the brain, which may foster changes in microbial communities that could contribute to neurodegenerative processes.
- * It highlights two main sources of bacteria that can reach the brain: oral dysbiosis in dental pockets and gut microbiota, and emphasizes the need for further research into these connections.
Polyglucosan bodies are accumulations of insoluble glucose polymers and proteins that form intracytoplasmic inclusions in the brain, large numbers of which can be indicative of neurodegenerative diseases such as Lafora disease. Montserrat orioles () are an icterid passerine endemic to Montserrat with conservation populations maintained in captivity abroad. We demonstrate that polyglucosan bodies are unusually abundant in the cerebellar molecular and Purkinje cell layers and cerebellar peduncles of captive-bred and wild-caught Montserrat orioles.
View Article and Find Full Text PDFIncrease in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology.
Acta Neuropathol Commun
June 2024
Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Joan XXIII 27-31, 08028, Barcelona, Spain.
Article Synopsis
- Wasteosomes (or corpora amylacea) are polyglucosan bodies linked to aging and neurodegenerative diseases, potentially serving a brain cleaning function.
- A study examined wasteosomes in 124 post-mortem FTLD patients across three proteinopathies (tau, TDP, and FUS), finding a higher accumulation in FTLD patients compared to controls, particularly in FTLD-FUS cases.
- Results indicated that while wasteosomes increased with disease duration in FTLD-TDP, they did not show this trend in FTLD-tau and FTLD-FUS, suggesting varying roles in disease progression among the proteinopathies.
Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition: Comprehensive Analysis Using Immunohistochemistry, Proteomics, and a Literature Review.
Int J Mol Sci
April 2024
Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
This study aimed to elucidate the similarities and differences between amyloid-forming corpora amylacea (CA) in the prostate and lung, examine the nature of CAs in cystic tumors of the atrioventricular node (CTAVN), and clarify the distinctions between amyloid-forming CA and spheroid-type amyloid deposition. We conducted proteomics analyses using liquid chromatography-tandem mass spectrometry with laser microdissection and immunohistochemistry to validate the characteristics of CAs in the lung and prostate. Our findings revealed that the CAs in these organs primarily consisted of common proteins (β2-microglobulin and lysozyme) and locally produced proteins.
View Article and Find Full Text PDFCorpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease.
Front Neurosci
February 2024
Brain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
Introduction: Severity and distribution of aggregated tau and neurofibrillary tangles (NFT) are strongly correlated with the clinical presentation of Alzheimer's disease (AD). Clearance of aggregated tau could decrease the rate of NFT formation and delay AD onset. Recent studies implicate corpora amylacea (CA) as a regulator of onset or accumulation of tau pathology.
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