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Exploring the photosensitizing potential of Nanoliposome Loaded Improved Toluidine Blue O (NLITBO) Against Streptococcus mutans: An in-vitro feasibility study.
PLoS One
October 2024
Basic Medical and Dental Sciences Dept, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Article Synopsis
- Streptococcus mutans is a key player in dental caries due to its acid production and biofilm survival, leading to a shift towards using antimicrobial Photodynamic Therapy (PDT) with Toluidine Blue O (TBO) as a potential treatment.
- The study aims to encapsulate improved TBO (ITBO) in nanoliposomes (NLITBO), analyze its properties, and assess its antibacterial effectiveness against Streptococcus mutans in lab settings.
- Results indicate that NLITBO showed effective drug loading and stability, with antibacterial activity evaluated through zone of inhibition and minimum inhibitory concentration tests using red light to enhance its effects.
Amentoflavone maintaining extracellular matrix homeostasis and inhibiting subchondral bone loss in osteoarthritis by inhibiting ERK, JNK and NF-κB signaling pathways.
J Orthop Surg Res
October 2024
Department of Orthopedics, Nanchang Hongdu Hospital of TCM, Nanchang, China.
Amentoflavone (AF), a plant biflavone isolated from Selaginella sinensis ethanol extract, is characterized by anti-inflammatory and anti-oxidant properties. According to previous studies, inflammation and oxidative stress are closely related to the pathophysiology of osteoarthritis (OA). However, the effects and mechanisms of AF on OA have not been elucidated.
View Article and Find Full Text PDFN-butanol extract of Broussonetia papyrifera (L.) L'Hér. ex Vent root bark alleviates atopic dermatitis by targeting E3 ubiquitin ligase WWP1 to promote NLRP3 degradation.
Biomed Pharmacother
November 2024
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510699, China. Electronic address:
Background: Broussonetia papyrifera (L.) L'Hér. ex Vent (B.
View Article and Find Full Text PDFThe DHODH inhibitor teriflunomide impedes cell proliferation and enhances chemosensitivity to daunorubicin (DNR) in T-cell acute lymphoblastic leukemia.
Ann Hematol
December 2024
Center for Clinical Molecular Laboratory Medicine of Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological tumor that requires novel treatment strategies, especially for relapsed/refractory cases. Dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine synthesis pathway, has been identified as a potential target for tumors. Besides, Teriflunomide (TRF) is a DHODH inhibitor with anticancer effects; however, its role in T-ALL remains poorly understood.
View Article and Find Full Text PDFAntibacterial and Antiallergic Effects of Three Tea Extracts on Histamine-Induced Dermatitis.
Pharmaceuticals (Basel)
September 2024
Guangzhou Zhongzhuang Meiye Cosmetics Co., Ltd., Guangzhou 510006, China.
Article Synopsis
- Atopic dermatitis (AD) is a long-lasting skin condition that can cause itching and inflammation, and it's connected to genetics.
- Researchers are studying how different types of Chinese tea extracts can help reduce the symptoms of itchy skin caused by histamine.
- The study found that the three tea extracts (black, green, and white) can help ease skin itching and inflammation, with black tea showing the best results.
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