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Nucleotidyltransferase toxin MenT extends aminoacyl acceptor ends of serine tRNAs to control Mycobacterium tuberculosis growth.
Nat Commun
November 2024
Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Toxins of toxin-antitoxin systems use diverse mechanisms to inhibit bacterial growth. In this study, we characterize the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis in humans. We show that MenT3 is a robust cytidine specific tRNA nucleotidyltransferase in vitro, capable of modifying the aminoacyl acceptor ends of most tRNA but with a marked preference for tRNA, to which long stretches of cytidines are added.
View Article and Find Full Text PDFAltered dNTP pools accelerate tumor formation in mice.
Nucleic Acids Res
November 2024
Department of Medical Biochemistry and Biophysics, Umeå University, Linnaeus väg 6, Umeå, SE 90736, Sweden.
Article Synopsis
- Changes in deoxyribonucleoside triphosphate (dNTP) pools are tied to higher mutation rates and genome instability in unicellular organisms, but their role in mammalian tumor development is not well understood.
- A mouse model with a specific mutation in ribonucleotide reductase (RRM1-Y285A) showed decreased enzyme activity, leading to reduced dATP and dGTP levels, resulting in shorter lifespans and earlier tumor onset.
- Analysis of the tumors indicated unique mutational signatures similar to those found in human cancers with related mutations in ribonucleotide reductase, suggesting that dNTP metabolism mutations may drive cancer development.
Mitigating Cold Ischemic Injury: HTK, UW and IGL-2 Solution's Role in Enhancing Antioxidant Defence and Reducing Inflammation in Steatotic Livers.
Int J Mol Sci
August 2024
Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain.
Liver transplantation remains the only definitive treatment for end-stage liver diseases. However, the increasing prevalence of fatty liver disease among potential donors exacerbates the shortage of suitable organs. This study evaluates the efficacy of the preservation solution Institut Georges Lopez-2 (IGL-2) compared to Histidine-Tryptophan-Ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions in mitigating ischemia-reperfusion injury (IRI) in steatotic livers.
View Article and Find Full Text PDFRole of Heavy Water in Modified University of Wisconsin Solution for Extended Cold Storage of Rat Liver.
Transplant Proc
October 2024
Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Department of Transplant Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
To resolve the critical donor shortage worldwide, enlarging the potential donor pool to include expanded criteria donors is necessary. Despite numerous attempts to establish new preservation solutions, no dramatic innovation has occurred since University of Wisconsin (UW) solution displaced Euro Collins' solution; UW solution remains the global gold standard. We previously developed a heavy water (DO)-containing organ storage solution, Dsol, which is effective for livers subjected to extended cold storage (CS), and reported its effectiveness.
View Article and Find Full Text PDFAltered S-AdenosylMethionine availability impacts dNTP pools in Saccharomyces cerevisiae.
Yeast
August 2024
Department of Biological Sciences, Northern Kentucky University, Highland Heights, Kentucky, USA.
Saccharomyces cerevisiae has long been used as a model organism to study genome instability. The SAM1 and SAM2 genes encode AdoMet synthetases, which generate S-AdenosylMethionine (AdoMet) from Methionine (Met) and ATP. Previous work from our group has shown that deletions of the SAM1 and SAM2 genes cause changes to AdoMet levels and impact genome instability in opposite manners.
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