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Comparison of clinical performance between late and standard total-body [ Ga]Ga-PSMA-11 in biochemical recurrent prostate cancer.

Eur J Nucl Med Mol Imaging

November 2024

Department of Nuclear Medicine, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China.

Article Synopsis
  • Late [Ga]Ga-PSMA-11 PET/CT imaging shows improved lesion detection in prostate cancer compared to standard techniques, but its clinical use has been limited due to lower image quality with short axial field of view (SAFOV) systems.
  • This study investigates the efficacy of late LAFOV [Ga]Ga-PSMA-11 PET/CT with forced diuresis, analyzing its diagnostic accuracy and effects on treatment decisions for patients with biochemical recurrence after prostate surgery.
  • Findings reveal that late LAFOV PET/CT provides better image quality and a significantly higher rate of positive scans (80.31%) compared to standard scans (65.35%), indicating its potential to influence patient management.
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Positron emission tomography (PET) with F-FDG is being used more frequently to evaluate primary pelvic tumors (PTs). However, a standardized hydration protocol is essential for an optimal diuretic effect and constant results. We reviewed 109 patients with PTs who had undergone F-FDG PET/CT examinations between November 2006 and April 2013.

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Background: Lithiasis is a common and recurrent disease. Flexible ureteroscopy (fURS) is the cornerstone of laser treatment of kidney stones. Kidney stones destruction requires its laser pulverization into small fragments in order to remove them through the ureter or improve their spontaneous expulsion along the urinary tract.

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Article Synopsis
  • A case was reported of a 39-year-old male living with HIV who developed hypercalcemia and acute kidney damage due to immune reconstitution inflammatory syndrome (IRIS) and disseminated Mycobacterium avium infection.
  • The patient experienced significant weight loss, muscle weakness, and had laboratory findings confirming high serum calcium levels and kidney damage despite being on antiretroviral therapy and other medications.
  • Treatment involving diuretics, bisphosphonates, and calcitonin successfully normalized calcium levels and improved kidney function, highlighting the rare but critical nature of hypercalcemia linked to IRIS in HIV patients.
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