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Classification of Breast Cancer Through the Perspective of Cell Identity Models.
Adv Exp Med Biol
January 2025
INSERM, Bergonie Cancer Institute, University of Bordeaux, Bordeaux, France.
The mammary epithelium has an inner luminal layer that contains estrogen receptor (ER)-positive hormone-sensing cells and ER-negative alveolar/secretory cells, and an outer basal layer that contains myoepithelial/stem cells. Most human tumours resemble either hormone-sensing cells or alveolar/secretory cells. The most widely used molecular classification, the Intrinsic classification, assigns hormone-sensing tumours to Luminal A/B and human epidermal growth factor 2-enriched (HER2E)/molecular apocrine (MA)/luminal androgen receptor (LAR)-positive classes, and alveolar/secretory tumours to the Basal-like class.
View Article and Find Full Text PDFConvergent Patterns of Karyotype Evolution Underlying Karyotype Uniformity in Conifers.
Adv Sci (Weinh)
December 2024
Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations / State Key Laboratory of Plant Diversity and Specialty Crops, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Karyotype diversity plays an important role in speciation and diversification. However, gymnosperms, particularly conifers, exhibit remarkable karyotype uniformity. To explore the evolutionary processes shaping karyotypes in gymnosperms, the karyotype evolutionary history is reconstructed through comparative genomic analyses.
View Article and Find Full Text PDFThe interplay of the translocase activity and protein recruitment function of PICH in ultrafine anaphase bridge resolution and genomic stability.
Nucleic Acids Res
December 2024
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Incomplete sister centromere decatenation results in centromeric ultrafine anaphase bridges (UFBs). PICH (PLK1-interacting checkpoint helicase), a DNA translocase, plays a crucial role in UFB resolution by recruiting UFB-binding proteins and stimulating topoisomerase IIα. However, the involvement of distinct PICH functions in UFB resolution remains ambiguous.
View Article and Find Full Text PDFA Detailed Karyological Investigation of three Endemic Cobitis Linnaeus, 1758 Species (Teleostei, Cobitidae) in Anatolia, Türkiye.
Cytogenet Genome Res
December 2024
Department of Cell Biology, Faculty of Science, Charles University, Prague, Czechia.
Introduction: Comparative cytogenetics is a vital approach for diagnosing chromosome abnormalities and identifying species-specific patterns. In this study, chromosomal analysis of three Anatolian endemic Cobitis species was performed: Cobitis bilseli, C. fahireae, and C.
View Article and Find Full Text PDFPast innovations and future possibilities in plant chromosome engineering.
Plant Biotechnol J
November 2024
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Article Synopsis
- Plant chromosome engineering allows the transfer of desirable traits into plants by incorporating segments from alien chromosomes, enhancing modern plant breeding.
- Successful examples include rye chromosome segments for disease resistance and innovative techniques like centromere engineering and CRISPR/Cas technology for chromosomal manipulation.
- These advancements broaden the possibilities for genetic improvement in crops, paving the way for future innovations in plant breeding.
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