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Multifactor Analyses of Frontal Cortex Lipids in the APP/PS1 Model of Familial Alzheimer's Disease Reveal Anomalies in Responses to Dietary n-3 PUFA and Estrogenic Treatments.
Genes (Basel)
June 2024
Membrane Physiology and Biophysics, Department of Physics, School of Sciences, University of La Laguna, 38206 Tenerife, Spain.
Brain lipid homeostasis is an absolute requirement for proper functionality of nerve cells and neurological performance. Current evidence demonstrates that lipid alterations are linked to neurodegenerative diseases, especially Alzheimer's disease (AD). The complexity of the brain lipidome and its metabolic regulation has hampered the identification of critical processes associated with the onset and progression of AD.
View Article and Find Full Text PDFEvidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis.
J Mol Med (Berl)
March 2024
University of Barcelona, 08907, Hospitalet de LLobregatBarcelona, Spain.
Article Synopsis
- ALS is a neurodegenerative disease affecting motor neurons, with its causes still unclear, but recent research shows changes in the lipid composition of lipid rafts in ALS patients' spinal cords.
- Significant alterations were found in fatty acid levels, including increased n-9/n-7 monounsaturated fatty acids and arachidonic acid, pointing to destabilization in the lipid rafts.
- These changes contribute to more fluid and less viscous membranes in ALS, indicating a disruption in lipid metabolism rather than oxidative stress.
Pushing the boundaries of phosphorylase cascade reaction for cellobiose production II: Model-based multiobjective optimization.
Biotechnol Bioeng
February 2024
Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria.
The inherent complexity of coupled biocatalytic reactions presents a major challenge for process development with one-pot multienzyme cascade transformations. Kinetic models are powerful engineering tools to guide the optimization of cascade reactions towards a performance suitable for scale up to an actual production. Here, we report kinetic model-based window of operation analysis for cellobiose production (≥100 g/L) from sucrose and glucose by indirect transglycosylation via glucose 1-phosphate as intermediate.
View Article and Find Full Text PDFImaging the rotational mobility of carbon dot-gold nanoparticle conjugates using frequency domain wide-field time-resolved fluorescence anisotropy.
J Biomed Opt
May 2023
Bar Ilan University, The Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Ramat Gan, Israel.
Significance: Wide-field measurements of time-resolved fluorescence anisotropy (TR-FA) provide pixel-by-pixel information about the rotational mobility of fluorophores, reflecting changes in the local microviscosity and other factors influencing the fluorophore's diffusional motion. These features offer promising potential in many research fields, including cellular imaging and biochemical sensing, as demonstrated by previous works. Nevertheless, imaging is still rarely investigated in general and in carbon dots (CDs) in particular.
View Article and Find Full Text PDFDirectly imaging emergence of phase separation in peroxidized lipid membranes.
Commun Chem
January 2023
MSRH, Department of Chemistry, Imperial College London, WoodLane, London, W12 0BZ, UK.
Lipid peroxidation is a process which is key in cell signaling and disease, it is exploited in cancer therapy in the form of photodynamic therapy. The appearance of hydrophilic moieties within the bilayer's hydrocarbon core will dramatically alter the structure and mechanical behavior of membranes. Here, we combine viscosity sensitive fluorophores, advanced microscopy, and X-ray diffraction and molecular simulations to directly and quantitatively measure the bilayer's structural and viscoelastic properties, and correlate these with atomistic molecular modelling.
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