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Anti-allodynic effect of intrathecal antibodies against macrophage-inducible C-type lectin in spinal nerve ligation model in rat.
Heliyon
December 2024
Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, South Korea.
Introduction: Macrophage-inducible C-type lectin (Mincle) has emerged as a potential contributor to neuropathic pain induction and neuroinflammatory responses within the spinal cord. Moreover, evidence suggests a close association between toll-like receptor (TLR) and Mincle expression in myeloid cells. This study evaluated the effectiveness of Mincle antibodies in neuropathic pain and identified the epitope of these antibodies.
View Article and Find Full Text PDFThe Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies.
Toxins (Basel)
December 2024
School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690 525, Kerala, India.
The intricate combination of organic and inorganic compounds found in snake venom includes proteins, peptides, lipids, carbohydrates, nucleotides, and metal ions. These components work together to immobilise and consume prey through processes such as paralysis and hypotension. Proteins, both enzymatic and non-enzymatic, form the primary components of the venom.
View Article and Find Full Text PDFSublingual macrophage-associated ILDR2 contributes to immune tolerance via Treg induction.
Biochem Biophys Res Commun
January 2025
Department of Oral Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan; Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8549, Japan. Electronic address:
The sublingual mucosa (SLM) has been used for sublingual immunotherapy (SLIT) which has the potential to induce antigen-specific immune tolerance. We previously demonstrated the CD206 macrophages that were increased in the SLM after repeated antigen exposure. These macrophages showed high expression of the gene encoding ILDR2 (Ig-like domain-containing receptor 2), an immune checkpoint molecule.
View Article and Find Full Text PDFMolecular Mechanisms of Curdlan-Induced Suppression of NFATc1 Expression in Osteoclasts.
J Cell Biochem
January 2025
Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.
Article Synopsis
- - Curdlan, a β-glucan, inhibits the formation of osteoclasts—cells that break down bone—by binding to dectin-1, leading to reduced expression of NFATc1, a key factor for osteoclast differentiation.
- - The study investigates how curdlan disrupts RANKL-induced NFATc1 expression and finds that it also affects the NF-κB signaling pathway, which is crucial for NFATc1 activation.
- - Additionally, the research indicates a dectin-1-independent mechanism involving complement receptor 3 (CR3), suggesting that curdlan's effects on osteoclast differentiation are multifaceted and involve multiple pathways.
Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1-stimulated cells.
J Biol Chem
December 2024
Department of Genome Science and Microbiology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan; Life Science Innovation Center, University of Fukui, Fukui, Fukui, Japan.
Dectin-1, a C-type lectin, plays important roles in the induction of antifungal immunity. Caspase recruitment domain-containing protein 9 (CARD9) is essential for the dectin-1-induced production of cytokines through the activation of NF-κB. However, the molecular mechanisms underlying the dectin-1-mediated activation of CARD9 have not been fully elucidated.
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