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Effects of two infectious bursal disease vaccine virus strains on hepatic microsomal enzyme activities in chickens.
Acta Vet Hung
June 2006
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
The influence of two infectious bursal disease vaccines on the activities of hepatic microsomal enzymes aniline hydroxylase, ethylmorphine N-demethylase, NADPH-cytochrome c reductase, aryl sulphotransferase and p-nitrophenol UDP-glucuronyltransferase was investigated in chickens. The vaccines contained attenuated Winterfield 2512 and VMG-91 strains, respectively. The activities of enzymes were determined on postvaccination days 0, 2, 5 and 7.
View Article and Find Full Text PDFThe relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies.
Food Chem Toxicol
April 2006
World-wide Safety Sciences, Pfizer Global Research and Development, Groton, CT 06340, USA.
The purpose of this investigation was to examine the relationship among hepatic microsomal enzyme induction, liver weight, histological evidence of hepatic injury, and serum clinical chemistry markers of hepatic origin in the cynomolgus monkey. We report here the results from independent toxicology studies for 10 investigative drug candidates representing four therapeutic classes. Study conditions were selected to elicit target organ toxicity.
View Article and Find Full Text PDFBiochemical background of toxic interaction between tiamulin and monensin.
Chem Biol Interact
March 2004
Department of Toxicology, EGIS Pharmaceuticals Ltd., Bökényföldi út 116, H-1165 Budapest, Hungary.
Tiamulin, a diterpene antibiotic, is used for treatment of pulmonary and gastrointestinal infections in swine and poultry. Combined administration of tiamulin and ionophores (e.g.
View Article and Find Full Text PDFGenomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.
FASEB J
September 2003
Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77225, USA.
We report that CYP3a13 gene, located on mouse chromosome 5, spans 27.5 Kb and contains 13 exons. The transcription start site is 35 bp upstream of the coding region and results in a 109 bp 5' untranslated region.
View Article and Find Full Text PDFInhibition and possible induction of rat CYP2D after short- and long-term treatment with antidepressants.
J Pharm Pharmacol
November 2002
Polish Academy of Sciences, Institute of Pharmacology, Smetna 12, 31-343 Kraków, Poland.
The aim of this study was to investigate the influence of tricyclic antidepressants (imipramine, amitriptyline, clomipramine, desipramine), selective serotonin reuptake inhibitors (SSRIs: fluoxetine, sertraline) and novel antidepressant drugs (mirtazapine, nefazodone) on the activity of CYP2D, measured as a rate of ethylmorphine O-deethylation. The reaction was studied in control liver microsomes in the presence of the antidepressants, as well as in microsomes of rats treated intraperitoneally for one day or two weeks (twice a day) with pharmacological doses of the drugs (imipramine, amitriptyline, clomipramine, nefazodone 10 mg kg(-1) i.p.
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