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Background: The combination of methimazole and propranolol is considered an effective treatment regimen for hyperthyroidism in clinical practice; however, detrimental effects on the heart rate, bone metabolism and thyroid hormone levels have been reported. Therefore, the present study aimed to systematically review the efficacy and safety differences in patients with hyperthyroidism and the effects of treatment on heart rate, bone metabolism, cortisol, and adrenocorticotropic hormone levels using case-control studies.
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Drs. Uwakwe and Glick are from and Dr. Buethe was from the Department of Dermatology, SUNY Downstate Health Sciences University, Brooklyn, New York. Dr. Buethe currently is from the University of California San Diego/Rady Children's Hospital. Dr. Di Franco is from the Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York.
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