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TGFβ-mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound-induced skin fibrosis.
Cell Prolif
January 2025
State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Aberrant activation of dermal fibroblasts during wound healing often leads to debilitating fibrotic changes in the skin, such as scleroderma and keloids. However, the underlying cellular and molecular mechanisms remain elusive. Here, we established a wound-induced skin fibrosis (WISF) mouse model in mature adult mice, characterised by excessive deposition of collagen bundles, loss of dermal adipocytes, and enrichment of DPP4Ly6ATHY1 hypodermal interstitial adipocyte progenitors (HI-APs) and pericytes, resembling human fibrotic skin diseases.
View Article and Find Full Text PDFWound-induced triacylglycerol biosynthesis is jasmonoy-l-isoleucin and abscisic acid independent.
Plant Biol (Stuttg)
June 2023
Department for Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, Goettingen, Germany.
Article Synopsis
- Triacylglycerol (TAG) helps plants maintain lipid balance during stress, particularly after wounding where it accumulates as a storage form of fatty acids from damaged membranes.
- The study examined whether the phytohormones jasmonoyl-isoleucine (JA-Ile) and abscisic acid (ABA) are necessary for this TAG accumulation by analyzing certain mutant plants.
- Findings revealed that TAG accumulation occurs regardless of JA-Ile or ABA presence, with newly synthesized TAG primarily made of polyunsaturated fatty acids stored in lipid droplets, suggesting it serves as a temporary energy reserve after injury.
Wound-Induced Hair Neogenesis Model.
J Invest Dermatol
October 2022
Department of Dermatology, Johns Hopkins University, Baltimore, Maryland, USA; Department of Cell Biology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address:
Skin wounds in adult mammals typically heal with a fibrotic scar and fail to restore ectodermal appendages, such as hair follicles or adipose tissue. Intriguingly, new hair follicles regenerate in the center of large full-thickness wounds of mice in a process called wound-induced hair neogenesis (WIHN). WIHN is followed by neogenesis of dermal adipose tissue.
View Article and Find Full Text PDFWound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration.
Cold Spring Harb Perspect Biol
February 2023
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Adult mammals retain the remarkable ability to regenerate hair follicles after wounding. Wound-induced hair neogenesis (WIHN) in many ways recapitulates embryogenesis. The origin of the stem cells that give rise to a nascent hair follicle after wounding and the role of mesenchymal cells and signaling pathways responsible for this regenerative phenomenon are slowly being elucidated.
View Article and Find Full Text PDFSo similar yet so different: The distinct contributions of extrafascicular and fascicular phloem to transport and exudation in cucumber plants.
J Plant Physiol
April 2022
Institute of Plant Biology and Biotechnology, University of Muenster, Schlossplatz 8, 48143, Muenster, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Schlossplatz 8, 48143, Muenster, Germany. Electronic address:
Cucurbits have been used as phloem research models for many decades because their exudates can be accessed with ease. However, cucurbit plants possess two distinct phloem systems known as the fascicular phloem (FP) and extrafascicular phloem (EFP). Therefore, the molecular composition and function of certain exudates can be misinterpreted due to their unclear origin.
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