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Population pharmacokinetic modelling of cetirizine concentrations in human breast milk-A contribution from the ConcePTION project.
Basic Clin Pharmacol Toxicol
January 2025
Department of Pharmacy, Pharmacoepidemiology and Drug Safety Research Group, University of Oslo, Oslo, Norway.
Article Synopsis
- Cetirizine is an antihistamine used for treating allergies and is often prescribed to breastfeeding mothers, although its effects on infants through breast milk are not well-documented.
- A population pharmacokinetic (popPK) model was created using data from a study of 35 breastfeeding women to predict cetirizine levels in breast milk and calculate the relative infant dose (RID).
- The study found a mean RID of 1.99%, indicating low exposure for infants, and suggests that cetirizine is generally safe for use during breastfeeding.
Prevalence and factors associated with inappropriate continuation of stress ulcer prophylaxis at discharge.
BMJ Open Qual
May 2024
Internal Medicine, Michigan State University College of Human Medicine, East Lansing, Michigan, USA.
Article Synopsis
- Stress ulcer prophylaxis aims to reduce the risk of gastrointestinal ulcers and related mortality in critically ill patients, but it's often continued unnecessarily after discharge, leading to "polypharmacy."
- A study reviewed over 3,200 patients on medications like proton pump inhibitors (PPIs) or H2 blockers, finding 44% continued on these drugs inappropriately at discharge.
- Factors influencing inappropriate continuation included discharge location, length of hospital stay, mechanical ventilator usage, and type of medication used; a web-based initiative is being considered to address this issue.
Diphenhydramine and Migraine Treatment Failure in Pediatric Patients Receiving Prochlorperazine.
Pediatr Emerg Care
August 2024
From the Department of Pediatric Emergency Medicine, Nicklaus Children's Hospital.
Objectives: The objectives are to determine whether diphenhydramine coadministered with prochlorperazine versus prochlorperazine only is associated with a difference in the risk of migraine treatment failure, as measured by the need for additional therapy, hospitalization rates, and 72-hour return rates, and to compare extrapyramidal adverse effects between groups.
Methods: Retrospective cohort of patients aged 7 to 18 years treated in the emergency department for migraines using prochlorperazine with or without diphenhydramine between 2013 and 2019. Patients were included if they had International Classification of Diseases, Ninth or Tenth Revision, codes for migraine or unspecified headache and were treated with prochlorperazine as part of their initial migraine therapy.
Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease Population.
CPT Pharmacometrics Syst Pharmacol
December 2020
Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Elevated serum creatinine (S ) caused by the inhibition of renal transporter(s) may be misinterpreted as kidney injury. The interpretation is more complicated in patients with chronic kidney disease (CKD) due to altered disposition of creatinine and renal transporter inhibitors. A clinical study was conducted in 17 patients with CKD (estimated glomerular filtration rate 15-59 mL/min/1.
View Article and Find Full Text PDFDevelopment of a HILIC-MS/MS method for the quantification of histamine and its main metabolites in human urine samples.
Talanta
December 2020
KU Leuven, Laboratory for Pharmaceutical Analysis, Herestraat 49, 3000, Leuven, Belgium. Electronic address:
An LC-MS/MS method was developed enabling the separation and quantification of histamine and its main metabolites (imidazole acetaldehyde, imidazole acetic acid, methyl imidazole acetic acid, methyl histamine, acetyl histamine) in urine samples. A fast separation was achieved in 10 min on two HILIC columns connected in series by adopting a linear gradient followed by an isocratic hold. The sample preparation consisted of a simple dilution step wherein 10 μL of urine was diluted with acetonitrile (ACN) to a final volume comprising 95% ACN.
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