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Revealing mitochondrial architecture and functions with single molecule localization microscopy.
Biol Cell
January 2025
CNRS, Univ Rennes, IGDR [(Institut de Génétique et Développement de Rennes)]-UMR 6290, Rennes, France.
Understanding the spatiotemporal organization of components within living systems requires the highest resolution possible. Microscopy approaches that allow for a resolution below 250 nm include electron and super-resolution microscopy (SRM). The latter combines advanced imaging techniques and the optimization of image processing methods.
View Article and Find Full Text PDFLinear IgA bullous dermatosis-a fifty year experience of Warsaw Center of bullous diseases.
Front Immunol
January 2025
Department of Immunodermatology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Masovian, Poland.
Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disorder characterized by the presence of linear IgA deposits at the basement membrane zone (BMZ) by direct immunofluorescence (DIF). This entity was first described by Chorzelski and Jablonska from Warsaw Center of Bullous Diseases, Poland. The disease affects children and adults, whereby they differ in terms of clinical picture and course.
View Article and Find Full Text PDFLaser-based 3D printing and optical characterization of optical micro-nanostructures inspired by nocturnal insects compound eyes.
Sci Rep
January 2025
Center for Advanced Laser Technologies (CETAL), National Institute for Lasers, Plasma and Radiation Physics, Magurele-Ilfov, 077125, Romania.
Nature offers unique examples that help humans produce artificial systems which mimic specific functions of living organisms and provide solutions to complex technical problems of the modern world. For example, the development of 3D micro-nanostructures that mimic nocturnal insect eyes (optimized for night vision), emerges as promising technology for detection in IR spectral region. Here, we report a proof of principle concerning the design and laser 3D printing of all ultrastructural details of nocturnal moth Grapholita Funebrana eyes, for potential use as microlens arrays for IR detection systems.
View Article and Find Full Text PDFBrain state-dependent neocortico-hippocampal network dynamics are modulated by postnatal stimuli.
J Neurosci
January 2025
Department of Integrative Anatomy, Nagoya City University Graduate School of Medicinal Sciences.
Neurons in the cerebral cortex and hippocampus discharge synchronously in brain state-dependent manner to transfer information. Published studies have highlighted the temporal coordination of neuronal activities between the hippocampus and a neocortical area, however, how the spatial extent of neocortical activity relates to hippocampal activity remains partially unknown. We imaged mesoscopic neocortical activity while recording hippocampal local field potentials in anesthetized and unanesthetized GCaMP-expressing transgenic mice.
View Article and Find Full Text PDFMoxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity.
Life Sci Space Res (Amst)
February 2025
Department of General Surgery, the 306th Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, PR China; Department of General Surgery, the Ninth Medical Center of PLA General Hospital, Beijing 100101, PR China. Electronic address:
Background: Currently, there is limited research on the impact of abdominal infection on intestinal damage under microgravity conditions. Cordyceps polysaccharide (CPS), the main active ingredient of Cordyceps, has demonstrated various pharmacological effects, including anti-inflammatory, antioxidant, and immunomodulatory properties. Moxifloxacin (MXF) is a fourth-generation quinolone antibiotic that is believed to have a dual regulatory effect on immune system activation and suppression.
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