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Synergistic Anti-Cancer Effects of Isocnicin and Radiotherapy in Glioblastoma: A Natural Compound's Potential.
Biomedicines
December 2024
Laboratory of Pharmacognosy, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Background/objectives: Glioblastoma (GBM) is the most aggressive type of brain tumor in adults. Currently, the only treatments available are surgery, radiotherapy, and chemotherapy based on temozolomide (TMZ); however, the prognosis is dismal. Several natural substances are under investigation for cancer treatment.
View Article and Find Full Text PDFAnticarcinogenic effects of ursodeoxycholic acid in pancreatic adenocarcinoma cell models.
Front Cell Dev Biol
December 2024
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Changes to the composition of the microbiome in neoplasia, is termed oncobiosis, may affect tumor behavior through the changes to the secretion of bacterial metabolites. In this study we show, that ursodeoxycholic acid (UDCA), a bacterial metabolite, has cytostatic properties in pancreatic adenocarcinoma cell (PDAC) models. UDCA in concentrations corresponding to the human serum reference range suppressed PDAC cell proliferation.
View Article and Find Full Text PDFBiological evaluation of newly synthesized α-benzil monoxime thiocarbohydrazide derivatives as an antimicrobial and anticancer agent: In vitro screening and ADMET predictions.
Bioorg Med Chem Lett
December 2024
Department of Chemistry, PDEA's Baburaoji Gholap College, Sangvi, Pune 27, India. Electronic address:
The current comprehensive study showcases a meticulous synthesis of novel class of α-benzilmonoxime thiocarbohydrazide (BMOTC) derivatives, and manifesting their multifaceted potential as antibacterial, antifungal, and anticancer agents. The synthesis of target compounds was performed in three phases using literature methods. In the first step, benzilmonoxime is synthesized using benzil and hydroxyl amine hydrochloride, followed by benzilmonoxime imine using thiocarbohydrazide.
View Article and Find Full Text PDFA spheroid whole mount drug testing pipeline with machine-learning based image analysis identifies cell-type specific differences in drug efficacy on a single-cell level.
BMC Cancer
December 2024
CeMOS, Mannheim University of Applied Sciences, 68163, Mannheim, Germany.
Background: The growth and drug response of tumors are influenced by their stromal composition, both in vivo and 3D-cell culture models. Cell-type inherent features as well as mutual relationships between the different cell types in a tumor might affect drug susceptibility of the tumor as a whole and/or of its cell populations. However, a lack of single-cell procedures with sufficient detail has hampered the automated observation of cell-type-specific effects in three-dimensional stroma-tumor cell co-cultures.
View Article and Find Full Text PDFSemisynthesis and Antitumour Evaluation of Natural Derivatives from -Kaurene -15α-Angeloyloxykaur-l6-en-3β-ol Isolated from .
Int J Mol Sci
December 2024
Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
Article Synopsis
- Two natural -kaurene diterpenoids were extracted from a plant, and six new derivatives were synthesized for evaluation of their anti-tumor properties against three types of cancer cells (colon, liver, and melanoma).
- One synthesized compound showed the strongest anti-proliferative effects across all cell lines, with a notable IC value of around 2.5 μM, and further studies indicated that some derivatives induced a selective G2/M cell cycle arrest.
- Apoptosis analysis revealed that certain compounds led to high levels of cell death (up to 99% apoptosis), linked to mitochondrial dysfunction and the activation of the intrinsic apoptotic pathway, suggesting their potential as effective anticancer agents.
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