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Validation and Clinical Application of a Developed Pedal Coordination Assessment Device for Older Drivers.
Healthcare (Basel)
March 2025
National Institute of Technology, Tomakomai College, Tomakomai 059-1275, Japan.
: Automobiles are vital for older adults to maintain health and independence, yet aging-related declines in physical and cognitive functions may impair driving abilities. Compensatory driving behaviors can help maintain driving safety. : This study aims to (1) validate a newly developed pedal coordination assessment device reflecting aging effects and (2) examine its potential application by analyzing the relationship between pedal coordination ability, physical and cognitive functions, and driving abilities.
View Article and Find Full Text PDFAge-Related Differences in Lipopolysaccharide-Induced Delirium-like Behavior Implicate the Distinct Microglial Composition in the Hippocampus.
Int J Mol Sci
February 2025
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Physiology, School of Medicine, Southeast University, Nanjing 210009, China.
As the global population ages, the mechanisms underlying age-related susceptibility to delirium have attracted attention. Given the central role of microglia in the pathogenesis of inflammation-related delirium, we investigated the temporal dynamics of neurobehavioral changes and microglial responses, following lipopolysaccharide (LPS, 200 μg/kg) administration in young and old male C57BL/6 mice. Although a similar illness trajectory across 48 h post-treatment (HPT) was observed in both age groups, old-LPS mice exhibited worsened delirium-like behavior.
View Article and Find Full Text PDF27-Hydroxymangiferolic Acid Extends Lifespan and Improves Neurodegeneration in by Activating Nuclear Receptors.
Molecules
February 2025
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
27-Hydroxymangiferolic acid (27-HMA) is a naturally occurring compound in mango fruits that exhibits diverse biological functions. Here, we show that 27-HMA activates the transcriptional activity of farnesoid X receptor (FXR), a nuclear receptor transcription factor, extending the lifespan and healthspan in (). Meanwhile, the longevity-promoting effect of 27-HMA was attenuated in the mutants of and the FXR homologs, indicating that the longevity effects of 27-HMA in may depend on nuclear hormone receptors (NHRs).
View Article and Find Full Text PDFRetinal sensitivity above macular neovascularization under anti-VEGF therapy in exudative neovascular age-related macular degeneration.
BMC Ophthalmol
March 2025
Dep. of Ophthalmology, St. Franziskus Hospital, Muenster, Germany.
Purpose: Growth of macular neovascularization (MNV) associated with development of complete retinal pigment epithelial and outer retina atrophy (cRORA) been observed in eyes neovascular age-related macular degeneration (nAMD) under effective anti-vascular endothelial growth factor (VEGF) therapy. We aimed to evaluate the influence of the presence of MNV on the sensitivity of the overlaying retina both in patients with or without cRORA and to generate hypotheses about their association.
Methods: Pilot study on nAMD patients undergoing long-term anti-VEGF therapy that had also undergone microperimetry testing.
Elevated urinary phytoestrogens are associated with delayed biological aging: a cross-sectional analysis of NHANES data.
Sci Rep
March 2025
Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University, Hangzhou, China.
Dietary phytoestrogens have been suggested to provide protection against numerous age-related diseases. However, their effects on biological aging remain unclear. In this study, we cross-sectionally investigated the relationship between urinary phytoestrogen levels and indicators of biological aging using data from 7,981 adults who participated in the National Health and Nutrition Examination Survey 1999-2010.
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