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Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology.
Sci Rep
April 2022
Laboratory of Virus-Host Coevolution, Research Center for Infectious Diseases, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Article Synopsis
- * Researchers discovered that live-attenuated vaccines for pets made from CRFK cells were contaminated with a replication-competent feline ERV known as RD-114.
- * By using TALEN to knockout certain genes in CRFK cells, they created a new cell line (RDKO_CRFK) that doesn’t produce infectious RD-114, making it safer for developing vaccines without ERV contamination.
Characterization of DNA methylation and promoter activity of long terminal repeat elements of feline endogenous retrovirus RDRS C2a.
Virus Genes
February 2022
Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8528, Japan.
Endogenous retroviruses (ERVs) are genomic elements derived from retroviral infections in ancestral germ lines. Most ERVs are inactivated by genetic or epigenetic mechanisms, such as DNA methylation. RD-114-virus-related sequence (RDRS) C2a is a feline endogenous retrovirus present in all domestic cats; however, its expression and function are not clearly known.
View Article and Find Full Text PDFCorrigendum to "Susceptibility of domestic animals to pseudotype virus bearing RD-114 virus envelope protein" [Gene 567(2) (2015) 189-195].
Gene
March 2019
Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan; Laboratory of Virolution, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto, University, Kyoto, Japan. Electronic address:
Tracking the Continuous Evolutionary Processes of an Endogenous Retrovirus of the Domestic Cat: ERV-DC.
Viruses
April 2018
Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
An endogenous retrovirus (ERV) is a remnant of an ancient retroviral infection in the host genome. Although most ERVs have lost their viral productivity, a few ERVs retain their replication capacity. In addition, partially inactivated ERVs can present a potential risk to the host via their encoded virulence factors or the generation of novel viruses by viral recombination.
View Article and Find Full Text PDF[RD-114 virus story: from RNA rumor virus to a useful viral tool for elucidating the world cats' journey].
Uirusu
August 2017
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
RD-114 virus is a feline endogenous retrovirus (ERV) isolated from human rhabdomyosarcoma in 1971 and classified as endogenous gammaretrovirus in domestic cats (Felis catus). Based on the previous reports in 70's, it has been considered that a horizontal, infectious event occurred to transfer the virus from ancient baboon species to ancient cat species, whereupon it became endogenous in the cat species about several million years ago in Mediterranean Basin. Although it has been believed that all domestic cats harbor infectious RD-114 provirus in their genome, we revealed that cats do not have infectious RD-114 viral loci, but infectious RD-114 virus is resurrected by recombination between uninfectious RD-114 virus-related ERVs [here we designated them as RD-114-related sequences (RDRSs)].
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