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Objective: Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU.

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Modulation of the Th1/Th2 bias by an immunoglobulin histamine complex in the ovalbumin allergy mouse model.

Int Immunopharmacol

April 2003

Institut für Molekulare Medizin und Zellforschung, AG Tumorimmunologie/Vakzine, Universitätsklinikum Freiburg, Stefan-Meier-Str 8, D-79104 Freiburg, Germany.

Vaccination with the antiallergic drug Histaglobin is used to treat a broad range of human allergic diseases including bronchial asthma, allergic rhinitis, and atopic dermatitis. In order to further elucidate its functional activity, Histaglobin was investigated in an in vivo mouse allergy model. Mice were sensitized with ovalbumin either prior to or after Histaglobin treatment, and its antiallergic potential was evaluated.

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Aim: To evaluate therapeutic effects of histaglobin drugs (histaglobin and histaglobin-triplex) in patients with continuous allergic rhinitis (CAR) and chronic recurrent (idiopathic) urticaria (CRU).

Materials And Methods: The drugs were given to 45 patients with CAR and high sensitivity to household allergens confirmed by cutaneous diagnostic tests or high IgE level, and 40 patients with CRU with typical cutaneous lesions. The drugs were injected subcutaneously (a total of 6 injections, 2 ml of solution each) with the interval 2-3 or 3-4 days.

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A complex of histamine/human gamma-globulin (HhG) has been widely used in Japan for more than 25 years as a nonspecific hyposensitization drug in the treatment of allergic diseases. It has been reported that HhG decreases the number of eosinophils in the nasal secretions and peripheral blood of patients with allergy. In this study we used a mouse system to explore the possibility that HhG may actively inhibit the accumulation of eosinophils at inflammation sites.

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