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Purpose: This study aimed to elucidate the association between postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) and clinicopathological factors and intraoperative and postoperative epidural or intravenous patient-controlled analgesia (IV-PCA).

Methods: We reviewed data of 116 patients who underwent distal pancreatectomy at Gunma University Hospital from October 2000 to October 2019. Clinical POPF was defined as the International Study Group of Pancreatic Fistula grade B or C.

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The article analyses briefly the methods of modern treatment of destructive pancreatitis. The authors apply complex treatment the principal component of which is infusion of a drug mixture into the aorta after its direct puncture at the level of the 8th-9th thoracic vertebra. The mixture consists of procaine hydrochloride solution, heparin, morphocycline, ftorafur , diphenylhydramine hydrochloride, trimeperidine hydrochloride.

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Antimicrobial effect of lysozyme in combination with a wide set of antimicrobial drugs (38) was studied with respect to 74 bacterial cultures. It was shown that synergism of the antimicrobial effect in the presence of lysozyme was variable for drugs differing in the mechanism of their action and depended on the pathogen species. The most pronounced synergistic effect was observed with respect to grampositive bacteria with the use of many drugs such as benzylpenicillin, ampiox, morphocycline, erythromycin and others.

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