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Lecithin/sphingomyelin ratio and lamellar body count for fetal lung maturity: a meta-analysis.
Eur J Obstet Gynecol Reprod Biol
July 2013
Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.
Objective: To determine and compare the diagnostic accuracy of the lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) in the prediction of neonatal respiratory distress syndrome (RDS).
Study Design: A systematic review was performed to identify studies comparing either the L/S ratio or the LBC with the occurrence of RDS published between January 1999 and February 2009. Two independent reviewers performed study selection and data extraction.
Ultra-high dose of intra-amniotic or direct fetal intramuscular betamethasone for lung maturation in the preterm goat model.
Eur J Obstet Gynecol Reprod Biol
September 2012
Suleyman Demirel University, Faculty of Medicine, Department of Obstetrics and Gynecology, Isparta, Turkey.
Article Synopsis
- The study aimed to assess the impact of high doses of betamethasone administered either intra-amniotically or through fetal injections on the lung function of neonates in a goat model before preterm delivery.
- Despite the treatment, the group receiving intra-amniotic betamethasone showed a high incidence of stillbirths and lung damage compared to control, while maternal administration improved lung pressure-volume metrics.
- The arterial blood gas analysis indicated that the control group suffered from acid-base imbalances, highlighting the varied effects of the different dosing routes on neonatal outcomes.
Comparison of vaginal and transabdominal collection of amniotic fluid for fetal lung maturity tests.
J Matern Fetal Neonatal Med
July 2010
Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
Backgrounds: The lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) are two tests that can be used to estimate the probability of the occurrence of respiratory distress syndrome (RDS). Our objective was to compare the prognostic capacity of the L/S ratio and the LBC in the prediction of RDS from amniotic fluid that was obtained either transabdominally or vaginally.
Methods: Consecutive women undergoing amniotic fluid sampling for determination of fetal lung maturity were included.
A comparison of amniotic fluid fetal pulmonary phospholipids in normal and diabetic pregnancy.
Am J Obstet Gynecol
April 2002
Division of Perinatal Medicine, Department of Reproductive Medicine, University of California, San Diego, 92103-8433, USA..
Objective: Our purpose was to determine whether there are differences in the timing of the appearance of various amniotic fluid fetal pulmonary phospholipids in normal and diabetic pregnancy.
Study Design: A case-control study of 295 subjects with diabetes and 590 control subjects was performed by use of gestational age-matched amniocentesis specimens analyzed for lecithin/sphingomyelin (L/S) ratio, phosphatidylinositol (PI), and phosphatidylglycerol (PG) composition. Diabetic subjects were stratified according to type of diabetes, degree of blood glucose control, and birth percentile of the neonate.
Objective: To verify whether in high risk pregnancies, fetuses with altered Doppler flow velocimetry waveforms (FVW) are associated with both biochemical and/or biophysical changes in the amniotic fluid (AF) lung surfactant.
Materials And Methods: Hundred-eight high risk pregnancies were considered on the basis of a complete Doppler velocimetry study performed within 24 hrs before amniocentesis and delivery within 1 week from amniocentesis. From this group, 22 pregnancies were recruited as altered FVW cases on the basis of simultaneous alteration of Umbilical Artery Pulsatility Index (UA PI), and UA PI/MCA PI (Middle Cerebral Artery Pulsatility Index) ratio (UA/MCA); in all altered FVW group cases the Mean Uterine Artery Resistance Index (Ut RI) was also altered.
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