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Pharmacological interventions for antipsychotic-related sialorrhea: a systematic review and network meta-analysis of randomized trials.
Mol Psychiatry
September 2023
Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.
Antipsychotic-induced sialorrhea carries a significant burden, but evidence-based treatment guidance is incomplete, warranting network meta-analysis (NMA) of pharmacological interventions for antipsychotic-related sialorrhea. PubMed Central/PsycInfo/Cochrane Central database/Clinicaltrials.gov/WHO-ICTRP and the Chinese Electronic Journal Database (Qikan.
View Article and Find Full Text PDFPharmacological comparison of peristaltic effects in rats and mice.
J Pharmacol Toxicol Methods
March 2014
AbbVie, North Chicago, IL, USA.
Introduction: Conscious rodent models are commonly used to assess the effects of new chemical entities on propulsion (transit) time in the gastrointestinal system. This study was designed to compare three compounds clinically known to cause constipative (morphine sulfate and propantheline bromide) and laxative (metoclopramide hydrochloride) effects on transit time in rats and mice and to note if there are differences between the species.
Methods: Compounds were dosed in conscious rats and mice.
Influence of prokinetics on the gastrointestinal transit and residence times of activated charcoal.
J Pak Med Assoc
August 2002
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nnewi, Nigeria.
Objective: To find the effects of prokinetics, saline cathartics and different charcoal doses on the gastrointestinal transit and residence times of activated charcoal (AC).
Setting: Five undergraduate volunteers of College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria, were studied.
Methods: After an overnight fast, the volunteers were given 10 g and 20 g AC with and without saline cathartics, in a simple cross-over design in which the subjects served as their own control.
An improved method of evaluation of drug-evoked changes in gastric emptying in mice.
J Pharmacol Toxicol Methods
June 2003
Department of Integrative Pharmacology, R46R AP9-1, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6119, USA.
Introduction: The increased availability of transgenic mice prompts a need for the adaptation to mice of whole-animal assays traditionally performed in larger laboratory animals. Gastric emptying studies are frequently conducted in dogs and rats. Mouse-based gastric emptying models currently available often use inert, nonnutrient liquid meals containing nonabsorbable markers or radionuclides.
View Article and Find Full Text PDFEffect of altered gastric emptying and gastrointestinal motility on metformin absorption.
Br J Clin Pharmacol
October 2000
Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Princeton, NJ 08543, USA.
Aims: The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects.
Methods: An open-label, three treatment, three period crossover study was conducted in 11 healthy volunteers. Each subject received 550 mg metformin hydrochloride in solution alone; 5 min after a 10 mg i.
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