Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Promotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells.
Int J Mol Sci
July 2024
Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
Osteoporotic vertebral compression fractures (OVCFs) are the most prevalent fractures among patients with osteoporosis, leading to severe pain, deformities, and even death. This study explored the use of ectopic embryonic calvaria derived mesenchymal stem cells (EE-cMSCs), which are known for their superior differentiation and proliferation capabilities, as a potential treatment for bone regeneration in OVCFs. We evaluated the impact of EE-cMSCs on osteoclastogenesis in a RAW264.
View Article and Find Full Text PDFFibronectin binds integrin α5β1 to regulate macular neovascularization through the Wnt/β-catenin signaling pathway.
Exp Eye Res
May 2024
Department of Ophthalmology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China. Electronic address:
Article Synopsis
- Age-related macular degeneration (AMD) is a leading cause of vision loss among older adults, primarily due to macular neovascularization (MNV) and subretinal fibrosis, which are linked to changes in extracellular matrix protein composition.
- The study investigates the role of fibronectin (FN) and its receptor, integrin α5β1, in promoting MNV, using mouse models and a cell line to analyze FN expression and its molecular mechanisms through various assays.
- Results showed increased FN and α5β1 levels in models of MNV, and silencing FN led to reduced cell migration and blood vessel formation, indicating FN's significant role in the development of AMD and its potential targeting for treatment.
Giving bodies to ghosts: locating molecules in the very place where they exert their biological roles.
Eur J Histochem
January 2024
National Academy of Sciences, Accademia dei Lincei, Rome.
This paper reviews some of the goals of our investigations published over the years on Rivista di Istochimica Normale e Patologica, Basic and Applied Histochemistry, and the European Journal of Histochemistry - EJH. In a series of papers, we published some of the basic cytochemical features of the sperm cytodifferentiation process for the first time. This was a conceptual and practical prerequisite to the in situ quantitative evaluation of sperm DNA content.
View Article and Find Full Text PDFA comprehensive stem cell laboratory module with blended learning for medical students at Tongji University.
Biochem Mol Biol Educ
May 2024
Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, China.
The laboratory practice "Primary culture and directional differentiation of rat bone marrow mesenchymal stem cells (BMSCs)" is part of a required course for sophomore medical students at Tongji university, which has been conducted since 2012. Blended learning has been widely applied in medical courses. Based on a student-centered teaching philosophy, we reconstructed a comprehensive stem cell laboratory module with blended learning in 2021, aiming to facilitate students in enhancing their understanding of the multi-lineage differentiation potential of stem cells and improve their experimental skills, self-directed learning ability, and innovative thinking.
View Article and Find Full Text PDFCommentary on a Classic JHC Article on the Histochemical Measurement of DNA Content in Cells.
J Histochem Cytochem
June 2023
Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia.
This article comments on the significance of a highly cited review article on DNA cytochemical quantitation that was published in the in 2002 (David C. Hardie, T. Ryan Gregory, and Paul D.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!