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Comparison of the Role of Anticholinergics and α-1 Adrenergic Blockers in Bladder Management in Posterior Urethral Valves: A Pilot Randomized Control Trial.
Urol Int
October 2024
Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Introduction: Posterior urethral valve (PUV) is a major cause of congenital bladder dysfunction, often persisting despite treatment. Emerging therapies, including anticholinergics and α-1 blockers, offer potential but lack clear guidelines. This study evaluates their effectiveness in improving bladder function after valve fulguration.
View Article and Find Full Text PDFAlpha-2a adrenergic receptor activation in genetic absence epilepsy: An absence status model?
Epilepsia Open
April 2024
Department of Medical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey.
Objective: The objective of the study was to propose a candidate animal model of absence status epilepticus induced by specific alpha-2a adrenergic receptor (α2AR) activation. We also aim to investigate the responsiveness of this model to classical anti-status or anti-absence medications.
Methods: An α2AR agonist, dexmedetomidine (DEX), was injected intracerebroventricularly into adult rats with genetic absence epilepsy, and their electroencephalography (EEG) was recorded.
Review of Dopamine Antagonists for Nausea and Vomiting in Palliative Care Patients.
J Pain Palliat Care Pharmacother
March 2024
Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
Article Synopsis
- - Symptoms like nausea and vomiting are frequently experienced by patients in palliative care, and dopamine receptor antagonists are a key treatment option, particularly effective for nausea related to the chemoreceptor trigger zone and gut issues.
- - While these medications (e.g., haloperidol, olanzapine, prochlorperazine, and metoclopramide) can alleviate symptoms, they come with side effects including QTc prolongation and risks of tardive dyskinesia, especially in vulnerable populations like dementia patients.
- - The review outlines drug efficacy, pharmacokinetics, and pharmacodynamics, emphasizing the importance of understanding how these medications work and the need for careful dosage adjustments according to individual patient factors to enhance safety and effectiveness
Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone.
Front Cardiovasc Med
February 2022
Biomedical Engineering, California Polytechnic State University, San Luis Obispo, CA, United States.
Stimulating collateral arteriogenesis is an attractive therapeutic target for peripheral artery disease (PAD). However, the potency of arteriogenesis-stimulation in animal models has not been matched with efficacy in clinical trials. This may be because the presence of enlarged collaterals is not sufficient to relieve symptoms of PAD, suggesting that collateral function is also important.
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