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SOCS1 Inhibits IL-6-Induced CD155 Overexpression in Lung Adenocarcinoma.
Int J Mol Sci
November 2024
Laboratorio de Cancer Pulmonar, Departamento de Enfermedades Cronico-Degenerativas, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosio Villegas", Mexico City 14080, Mexico.
CD155, also known as the poliovirus receptor (PVR), is a crucial molecule in the development and progression of cancer, as its overexpression favors immune evasion and resistance to immunotherapy. However, little is known about the mechanisms that regulate its overexpression. Proinflammatory factors produced by various cellular components of the tumor microenvironment (TME) have been associated with CD155 expression.
View Article and Find Full Text PDFEnterovirus Antibodies: Friends and Foes.
Rev Med Virol
November 2024
Laboratoire de Virologie URL3610, Univ. Lille et CHU Lille, Lille, France.
Enteroviruses (EV) initiate replication by binding to their cellular receptors, leading to the uncoating and release of the viral genome into the cytosol of the host cell. Neutralising antibodies (NAbs) binding to epitopes on enteroviral capsid proteins can inhibit this infectious process through several mechanisms of neutralisation in vitro. Fc-mediated antibody effector functions such as antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis have also been described for some EV.
View Article and Find Full Text PDFA Novel Peptide from VP1 of EV-D68 Exhibits Broad-Spectrum Antiviral Activity Against Human Enteroviruses.
Biomolecules
October 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Article Synopsis
- Enteroviruses, including polioviruses and non-polio variants, are a significant health concern, with over 116 types affecting humans annually.
- A novel peptide called P25 from EV-D68 shows broad antiviral activity against multiple enterovirus species by targeting key viral structures and functions.
- P25 has the potential to serve as a universal anti-enterovirus drug candidate due to its ability to block viral receptor binding, inhibit viral genome release, and reduce the production of infectious viral particles.
Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer.
Nat Commun
October 2024
State Key Laboratory of Systems Medicine for Cancer, Renji-Med-X Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- Iron-loaded cancer-associated fibroblasts (FerroCAFs) contribute to immunosuppression in prostate cancer and are linked to negative clinical outcomes.
- FerroCAFs secrete proteins that recruit immunosuppressive myeloid cells and are found in various cancers, identified by a common cell surface marker.
- Inhibiting the Hmox1/iron/Kdm6b signaling pathway in FerroCAFs can enhance anti-tumor immunity and offers potential targets for cancer therapy.
Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and viral protein 2C-mediated replication complex formation.
J Virol
October 2024
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Article Synopsis
- - The study explores how the foot-and-mouth disease virus (FMDV) relies on host cell lipid metabolism, specifically through the enzyme stearoyl coenzyme A desaturase-1 (SCD1), to replicate effectively.
- - Researchers found that increasing SCD1 levels or adding oleic acid boosted FMDV replication in various cell lines and that inhibiting SCD1 significantly reduced replication and affected the formation of replication complexes.
- - The findings suggest that targeting SCD1 could be a promising strategy for developing new antiviral drugs against FMDV and other RNA viruses, as it plays a critical role in their replication process.
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