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High-fidelity predictions of diffusion in the brain microenvironment.
Biophys J
November 2024
eScience Institute, University of Washington, Seattle, Washington; Department of Chemical Engineering, University of Washington, Seattle, Washington; Department of Bioengineering, University of Washington, Seattle, Washington. Electronic address:
Article Synopsis
- Multiple-particle tracking (MPT) is a microscopy technique that enables the tracking of many nanoparticles in biological samples, especially useful for studying the brain's extracellular space (ECS).
- This study develops a machine learning pipeline to analyze changes in the ECS after injury, validating its effectiveness on various MPT data sets through high accuracy in predicting biological age and region differences.
- The machine learning approach identifies injury states linked to different exposure times, showing improved predictive capabilities and uncovering nonlinear relationships in nanoparticle diffusion not captured by traditional methods.
One-pot biocatalysis of potato rhamnogalacturonan and the role of its deacetylation in efficient inhibition of colon cancer cells and hydrogel mediated colon-targeted drug delivery.
Int J Biol Macromol
November 2024
Carbohydrate Enzyme Biotechnology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India. Electronic address:
Article Synopsis
- The study investigated the deacetylation of potato rhamnogalacturonan (PRG) using the enzyme CtPae12B, resulting in increased hydrolysis efficiency by a second enzyme, CtRGLf.
- A significant 98% deacetylation was achieved, improving the inhibitory effects of PRG-oligosaccharides on colon-cancer HCT-116 cells compared to acetylated versions.
- Additionally, the deacetylated PRG exhibited a more porous structure and better drug delivery properties, making it a promising material for colon-targeted therapies.
Skin Improvement Effects of Ultrasound-Enzyme-Treated Collagen Peptide Extracts from Flatfish () Skin in an In Vitro Model.
Int J Mol Sci
August 2024
Food Processing Research Group, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.
Collagen is considered to be an intercellular adhesive that prevents tissue stretching or damage. It is widely utilized in cosmetic skin solutions, drug delivery, vitreous substitutions, 3D cell cultures, and surgery. In this study, we report the development of a green technology for manufacturing collagen peptides from flatfish skin using ultrasound and enzymatic treatment and a subsequent assessment on skin functionality.
View Article and Find Full Text PDFAnti-Streptococcus mutans and anti-inflammatory effects of ginsenoside Compound K and enzyme-treated red ginseng extract (BTEX-K).
J Oral Biosci
December 2024
BTGin co., Ltd., 125-6, Techno 2-ro, Yuseong-gu, Daejeon, 34024, Republic of Korea.
Objectives: Dental caries, or tooth decay, is an oral health issue worldwide. Oral healthcare researchers are considering how to develop safe and effective preventive measures and treatments for dental caries. This study evaluated the potential applications of Compound K and BTEX-K, a Compound K-rich red ginseng extract, for the prevention and treatment of dental caries.
View Article and Find Full Text PDFA patient with anti-f in India identified by extensive immunohematologic workup.
Immunohematology
June 2024
Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, India.
Anti-f is produced by exposure to the compound antigen ce (f) on red blood cells (RBCs), expressed when both c and e are present on the same protein ( position). Although anti-f was discovered in 1953, there are few cases reported worldwide because the presence of anti-f is often masked by anti-c or anti-e and is not generally found as a single antibody. In the present case, anti-f was identified by using three-cell screening and 11-cell identification panels.
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