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A Case Series With Cysteamine-Isobionicamide Complex: Clues for Skin-Rejuvenating Activity.
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Scientis SA, Geneva, Switzerland.
Background: Skin aging is inevitable. Wrinkles, skin texture abnormalities, senile hyperpigmentation, loss of skin tone, dryness, atrophy, and telangiectasias represent some of the hallmarks of aged skin. Skin rejuvenation can be addressed by topical therapies, such as topical retinoids and antioxidants or physical modalities with energy-based devices, all providing acceptable outcomes.
View Article and Find Full Text PDFRecent clinical and mechanistic insights into vitiligo offer new treatment options for cell-specific autoimmunity.
J Clin Invest
January 2025
Department of Dermatology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Vitiligo is an autoimmune disease that has been recognized, stigmatized, and treated for millennia. Recent translational research has revealed key mechanisms of disease, including cellular stress, innate immune activation, T cell-mediated elimination of melanocytes from the skin resulting in clinically apparent white spots, as well as stem cell regeneration that reverses established lesions. Many of these pathways have been targeted therapeutically, leading to the first FDA-approved medication to reverse the disease, with many more in clinical trials.
View Article and Find Full Text PDFGlobal trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis.
World J Diabetes
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Background: Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM.
View Article and Find Full Text PDFDynamics and asymptotic profiles of a local-nonlocal dispersal SIR epidemic model with spatial heterogeneity.
Infect Dis Model
June 2025
Department of Mathematical Sciences, P.O. Box 15551, UAE Emirates Center for Mobility Research, United Arab Emirates University, Al Ain, United Arab Emirates.
This research investigates a novel approach to modeling an SIR epidemic in a heterogeneous environment by imposing certain restrictions on population mobility. Our study reveals the influence of partially restricting the mobility of the infected population, who are allowed to diffuse locally and can be modeled using random dispersion. In contrast, the non-infective population, which includes susceptible and recovered individuals, has more freedom in their movements.
View Article and Find Full Text PDFNeurofibromatosis with diffuse intestinal ganglioneuromatosis: a case report.
Transl Cancer Res
December 2024
Department of Pathology, Jieyang People's Hospital, Jieyang, China.
Background: Neurofibromatosis type 1 (NF-1), a rare autosomal dominant disorder, arises from gene mutations affecting neurofibromin, a Ras GTPase regulator. These mutations activate Ras proteins, triggering clinical symptoms such as skin spots, epilepsy, pain, and tumors. Although gastrointestinal stromal tumors are well-known in NF-1, diffuse intestinal ganglioneuromatosis remains an extremely rare complication.
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