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Mobility matters: a protocol to improve mobility and reduce length of stay in hospitalised older adults.
BMJ Open Qual
March 2025
Duke University, Durham, North Carolina, USA.
Functional decline in hospitalised older adults aged 65 and above is a significant clinical problem. Despite its adverse outcomes, the problem of not mobilising older adult patients in clinical settings remains. Existing evidence suggests that a mobility protocol can be effective in addressing this concern.
View Article and Find Full Text PDFPediatric MEK inhibitor-associated retinopathy: 8-year experience at a tertiary academic center and report of 2 cases.
J AAPOS
March 2025
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:
Background: An adverse effect of mitogen-activated protein kinase (MEK) inhibitors is MEK inhibitor-associated retinopathy (MEKAR), a fluid collection between the retinal pigment epithelium (RPE) and interdigitation zone (IZ) seen in up to 90% of adults taking these medications. MEKAR is not well described in children. The purpose of this study was to characterize MEKAR screening practices, identify cases of MEKAR, and describe their clinical presentations in children.
View Article and Find Full Text PDFNovel Chitosan-Magnetite-Silica Ternary Capsules for Highly Efficient Sequestration of Reactive Dyes from aqueous media.
Environ Res
March 2025
Department of chemistry, RTM Nagpur University, Nagpur, 440033, India. Electronic address:
The main goal of this study was to synthesize novel Chitosan Magnetite Silica (CMS) adsorbent capsules and apply them for effective sequestration of anionic dyes Remazol brilliant blue 19 (RB-19) and Remazol golden yellow G -17 (RY-17) dye. The CMS capsules were synthesized and applied for batch study and evaluated using statistical modelling. Various analytical techniques, such as Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Thermogravimetry-Differential Thermal Analysis (TG-DTA), Brunauer-Emmett-Teller (BET) surface area analysis, UV-Vis Spectrophotometry, and Vibrating Sample Magnetometry (VSM), were employed to validate the formation of the CMS.
View Article and Find Full Text PDFDesign and development of drug delivery nanocarriers based on liquid-liquid phase separation, improved stability, cell-penetration and anti-cancer effect.
Int J Biol Macromol
March 2025
College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan, China. Electronic address:
Liquid-liquid phase separation (LLPS) of nuclear pore complex (NPC) with nuclear transport proteins (NTPs) via intrinsically disordered regions (IDRs) plays a crucial role in the nucleocytoplasmic transport. The development of efficient targeted delivery systems based on LLPS has attracted widespread attention. Here, we developed nanocarriers of casein peptides, a natural intrinsically disordered proteins (IDPs), modified with fatty acids of different alkyl chains (C10-C18) and decorated by shellac for highly effective drug delivery and cancer therapy.
View Article and Find Full Text PDFWho are we bridging? Description of warfarin patients receiving injectable bridging therapy.
Thromb Res
March 2025
University of Utah College of Pharmacy, Department of Pharmacotherapy, 30 South 2000 East, Salt Lake City, UT 84112, USA; University of Utah Health Thrombosis Service, 6056 Fashion Square Drive, Suite 2420, Murray, UT 84107, USA.
Purpose: The evidence guiding the decision to provide injectable anticoagulant bridging therapy during periods of subtherapeutic warfarin anticoagulation is sparse. This study aims to identify the types of patients currently bridged within an academic medical center's Thrombosis Service, to highlight patient populations for future study of bridging outcomes.
Methods: This descriptive cohort study included patients taking warfarin managed by University of Utah Health Thrombosis Service who received outpatient enoxaparin bridging between January 1 and December 31, 2022.
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