Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356516PMC
http://dx.doi.org/10.1128/JVI.10.4.653-657.1972DOI Listing

Publication Analysis

Top Keywords

mutants murine
8
murine sarcoma
8
sarcoma virus
8
isolation temperature-sensitive
4
temperature-sensitive mutants
4
virus three
4
three separate
4
separate murine
4
virus nonproducer
4
nonproducer cell
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!