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Gastrointestinal absorption and its regulation of hawthorn leaves flavonoids.
Sci Rep
January 2025
School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Hawthorn leave flavonoids (HLF) are widely used as an herb or dietary supplements for cardio-cerebrovascular diseases. However, its gastrointestinal absorption behavior and mechanism have not been disclosed. In this study, gastrointestinal absorption and its regulation of 4''-O-glucosylvitexin (GLV), 2''-O-rhamnosylvitexin (RHV), vitexin (VIT), rutin (RUT) and hyperoside (HP) in HLF were investigated using in vitro, in situ and in vivo models.
View Article and Find Full Text PDFEvaluating Pharmacists' Knowledge of Food-Drug Interactions in Croatia: Identifying Gaps and Opportunities.
Pharmacy (Basel)
November 2024
Department of Pharmacy, University of Split School of Medicine, 21000 Split, Croatia.
Food-drug interactions (FDIs) are pharmacokinetic or pharmacodynamic changes in drug effects caused by the presence of specific foods. To identify and prevent FDIs, pharmacists, alongside other healthcare professionals, should possess a certain level of knowledge. This study aimed to assess knowledge of FDIs among Croatian pharmacists.
View Article and Find Full Text PDFAn integrated platform for investigating drug-microbial interactions to support pharmacomicrobiomics studies.
Talanta
February 2025
Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
Investigation of drug-microbial interactions has gained prominence due to the increasing need to study pharmacomicrobiomics. Previous research has revealed the microbiome's role in drug metabolism, influencing efficacy, bioavailability, and toxicity. Several potential interactions have reported between drugs and microbes, including bioaccumulation, biotransformation, and the influence of drugs on microbial growth.
View Article and Find Full Text PDFPharmacokinetics and safety of TBAJ-876, a novel antimycobacterial diarylquinoline, in healthy subjects.
Antimicrob Agents Chemother
October 2024
Global Alliance for TB Drug Development, New York, New York, USA.
TBAJ-876, a second-generation diarylquinoline with greater antimycobacterial activity and a potentially better safety profile compared with bedaquiline, is under development for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). A phase 1, first-in-human study of TBAJ-876, comprising a single-ascending dose (SAD) part including a food effect cohort, a multiple-ascending dose (MAD) part, and a relative bioavailability part of tablets versus oral suspension, was conducted on 137 healthy adults. A drug-drug interaction study was conducted on 28 healthy adults to evaluate the effects of TBAJ-876 on a cytochrome P450 3A4 substrate (midazolam) and a P-glycoprotein substrate (digoxin).
View Article and Find Full Text PDFUnderstanding adefovir pharmacokinetics as a component of a transporter phenotyping cocktail.
Eur J Clin Pharmacol
July 2024
Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Gleueler Straße 24, Cologne, 50931, Germany.
Article Synopsis
- Adefovir was studied to understand how it interacts with renal transporters when combined with other drugs, showing a 20% increase in systemic exposure when used together with metformin, sitagliptin, pitavastatin, and digoxin.
- A population pharmacokinetic (popPK) model was used to analyze data from 24 healthy subjects, revealing that adefovir's absorption and bioavailability were significantly higher during combination therapy compared to when it was administered alone.
- The findings indicate that while co-administering drugs mainly influenced adefovir's absorption and conversion, its renal elimination process remained unchanged, suggesting limited drug-drug interactions in this context.
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