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The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use.
Ther Adv Psychopharmacol
May 2024
Institute of Pharmaceutical Sciences, King's College London, London, UK.
Tricyclic antidepressants (TCAs) remain widely prescribed for depression and many other conditions. There may be important differences between individual TCA in regard to their overdose toxicity and their cardiac toxicity in clinical use. We conducted a systematic review to compare the toxicity of individual TCA in overdose and the risk of serious adverse cardiac events occurring with therapeutic doses.
View Article and Find Full Text PDFEmpagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication.
Cardiovasc J Afr
June 2023
Physiology Department, Hacettepe University, Gaziantep, Turkey.
Aim: Empagliflozin (EMPA) is a sodium-glucose transporter-2 inhibitor used in the treatment of type 2 diabetes and has positive effects on cardiovascular outcomes. Amitriptyline (AMT) can be used in many clinical indications but leads to cardiotoxicity by causing QT prolongation. Our aim in this study was to determine how the effects of the concomitant use of empagliflozin and amitriptyline, which have been shown to have effects on sodium and calcium metabolism in cardiomyocytes, would cause an effect on QT and QTc intervals in clinical practice.
View Article and Find Full Text PDFEffect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
J Pharm Pharmacol
March 2023
Dokuz Eylul University, School of Medicine, Department of Medical Pharmacology, Izmir, Turkey.
Objectives: The aim of this study is to evaluate the protective effect of nicorandil, a selective mitochondrial KATP channel opener, on QT prolongation and myocardial damage induced by amitriptyline.
Methods: The dose of amitriptyline (intraperitoneal, i.p.
Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports.
Clin Toxicol (Phila)
May 2022
Department of Emergency Medicine, Division of Medical Toxicology, Boston Children's Hospital, Boston, MA, USA.
Introduction: Lipid emulsion therapy (LET) has been most thoroughly studied to reverse local anesthetic systemic toxicity (LAST). Case reports suggest that LET can successfully rescue cardiovascular collapse from bupropion, amitriptyline, and propranolol. The efficacy of LET against refractory hypotension and dysrhythmias from diphenhydramine, a commonly ingested lipophilic cardiotoxic agent, is less well described.
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