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Lysozyme-targeted liposomes for enhanced tubular targeting in the treatment of acute kidney injury.
Acta Biomater
January 2025
The State Key Laboratory of Functions and Applications of MediEucal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou Province, China; The Guizhou Provincial Scientific and Technologic Innovation Base ([2023]003), Guizhou Medical University, Guiyang 550025, Guizhou Province, China. Electronic address:
Acute kidney injury (AKI) is defined by the release of pro-inflammatory factors, leading to structural damage in renal tubules and subsequent tubular cell injury and death. Delivering drugs specifically to renal tubules to mitigate tubular cell damage holds potential for AKI treatment. In this work, we developed functional liposomes (LZM-PLNPs-TP) designed to bypass the glomerular filtration barrier and target tubules by leveraging the unique structural and pathological characteristics of glomeruli and tubules.
View Article and Find Full Text PDFAcute low temperature and lipopolysaccharide differentially modulated the innate immune and antioxidant responses in a subtropical fish, the pacu (Piaractus mesopotamicus).
Fish Physiol Biochem
February 2025
Aquaculture Center of UNESP, São Paulo State University (UNESP), Jaboticabal, Sao Paulo, Brazil.
Exogenous factors such as low water temperature can be stressful and elicit negative immune system effects, especially for fish, which are ectothermic. Stress and immune responses require energy overload, which can affect the cellular redox balance, causing oxidative damage. These overall responses impair the animal's health and negatively affect fish farming.
View Article and Find Full Text PDFGenetic deletion of the apoptosis associated speck like protein containing a card in LysM macrophages attenuates spinal cord injury by regulating M1/M2 polarization through ASC-dependent inflammasome signaling axis.
Exp Neurol
December 2024
Clinical Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, PR China; Anhui Key Laboratory of Tissue Transplantation, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, PR China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu, Anhui 233030, PR China; Anhui Province Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu Medical University, Bengbu, Anhui 233030, PR China; Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials, Bengbu Medical University, Bengbu, Anhui 233030, PR China. Electronic address:
Article Synopsis
- The study examines the role of ASC, a protein important for inflammasome activation, in neuroinflammation due to spinal cord injury (SCI), emphasizing the need to understand its function in specific cell types, particularly macrophages.
- Researchers used a mouse model with macrophage-specific knockout of ASC and found reduced macrophage infiltration and altered immune responses that favor healing during SCI recovery.
- The findings suggest that targeting ASC in peripheral macrophages might improve nerve function recovery after SCI, presenting a potential new avenue for treatment strategies.
Clonal monocytosis of renal significance.
Kidney Int
December 2024
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:
Clonal monocytosis reflects a preneoplastic or neoplastic sustained increase in the absolute monocyte count in the absence of reactive causes. Causes of clonal monocytosis include clonal cytopenias with monocytosis and acute and chronic myeloid neoplasms. Chronic myelomonocytic leukemia is a prototypical myelodysplastic/myeloproliferative overlap neoplasm in adults, characterized by sustained peripheral blood monocytosis.
View Article and Find Full Text PDFAcute salivary antimicrobial peptide secretion response to different exercise intensities and durations.
Am J Physiol Regul Integr Comp Physiol
December 2024
Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Japan.
Antimicrobial peptides, key players of innate mucosal immunity in the oral cavity, exert antibacterial and bacteriolytic effects. This study aimed to clarify the effects of acute exercise at different intensities and durations on salivary antimicrobial peptide levels. In a randomized crossover trial, 14 young healthy untrained men performed intensity trials [cycling at 35%, 55%, and 75% of maximal oxygen uptake (V̇o) for 30 min] and duration trials (cycling at 55% V̇o for 30, 60, and 90 min).
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