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Hot and cold executive function among pediatric attention deficit hyperactivity disorder with and without coexisting oppositional defiant disorder.
Int J Dev Neurosci
August 2024
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Science, Mashhad, Iran.
Background: Executive function is a high-level set of cognitive processes related to goal-directed behaviors including two conceptual subtypes of hot (emotional) and cold (cognitive) executive function (to abbreviate EF). EF deficits in attention deficit hyperactivity disorder (ADHD) leads to significant social impairments in the home, school, and community. Today the type and the extent of executive function defects in ADHD are still debated in studies.
View Article and Find Full Text PDFRepriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication.
Nucleic Acids Res
May 2021
Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.
To bypass a diverse range of fork stalling impediments encountered during genome replication, cells possess a variety of DNA damage tolerance (DDT) mechanisms including translesion synthesis, template switching, and fork reversal. These pathways function to bypass obstacles and allow efficient DNA synthesis to be maintained. In addition, lagging strand obstacles can also be circumvented by downstream priming during Okazaki fragment generation, leaving gaps to be filled post-replication.
View Article and Find Full Text PDFRecent advances in understanding endocrine disruptors: DDT and related compounds.
Fac Rev
November 2020
Department of Veterinary Physiology & Pharmacology, Texas A&M University, Texas, USA.
Endocrine-disrupting compounds (EDCs) are environmental contaminants that modulate estrogen, androgen, and thyroid hormone receptor signaling and it has been hypothesized that human exposures to EDCs induce multiple adverse health effects. Some of these responses include male and female reproductive tract problems, obesity, and neurological/neurobehavior deficits. Extensive laboratory animal and some human studies support the EDC hypothesis.
View Article and Find Full Text PDFBreast and prostate glands affected by environmental substances (Review).
Oncol Rep
April 2021
Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Arica 1000000, Chile.
Environmental endocrine disruptor chemicals are substances that can alter the homeostasis of the endocrine system in living organisms. They can be released from several products used in daily activities. Once in the organism, they can disrupt the endocrine function by mimicking or blocking naturally occurring hormones due to their similar chemical structure.
View Article and Find Full Text PDFLost opportunities for cancer prevention: historical evidence on early warnings with emphasis on radiofrequency radiation.
Rev Environ Health
December 2021
The Environment and Cancer Research Foundation, Örebro, Sweden.
Some historical aspects on late lessons from early warnings on cancer risks with lost time for prevention are discussed. One current example is the cancer-causing effect from radiofrequency (RF) radiation. Studies since decades have shown increased human cancer risk.
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