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Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease.
Sci Transl Med
January 2025
Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91052 Erlangen, Germany.
Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in intestinal epithelial cells (IECs) of patients with IBD and show that impaired fusion is sufficient to drive chronic intestinal inflammation.
View Article and Find Full Text PDFCortex-specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-like Behaviors in Mice.
J Neurosci
January 2025
Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China, 350122.
The development of the nervous system is a complex process, with many challenging scientific questions yet to be resolved. Disruptions in brain development are strongly associated with neurodevelopmental disorders, such as intellectual disability and autism. While the genetic basis of autism is well established, the precise pathological mechanisms remain unclear.
View Article and Find Full Text PDFOlink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer.
J Proteome Res
January 2025
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China.
Comprehensive protein profiling in intestinal tissues provides detailed information about the pathogenesis of colorectal cancer (CRC). This study quantified the expression levels of 92 oncology-related proteins in tumors, paired para-carcinoma tissues, and remote normal tissues from a cohort of 52 CRC patients utilizing the Olink technology. The proteomic profile of normal tissues closely resembled that of para-carcinoma tissues while distinctly differing from that of tumors.
View Article and Find Full Text PDFEmerging spp. infections in Europe: characterization of human clinical isolates from German patients.
Front Microbiol
December 2024
Department Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Bacteria of the genus are widely distributed in water bodies around the world. Some species have been identified as human pathogens causing intestinal and a variety of extraintestinal infections. In Germany, information on diseases caused by is rare, because infections are not notifiable in Germany.
View Article and Find Full Text PDFBaseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis.
J Exp Med
January 2025
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Immunotherapy-related colitis (irC) frequently emerges as an immune-related adverse event during immune checkpoint inhibitor therapy and is presumably influenced by the gut microbiota. We longitudinally studied microbiomes from 38 ICI-treated cancer patients. We compared 13 ICI-treated subjects who developed irC against 25 ICI-treated subjects who remained irC-free, along with a validation cohort.
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