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Roles for the long non-coding RNA / in pancreatic beta cell function.
iScience
January 2025
Section of Cell Biology and Functional Genomics, Department of Medicine, Endocrinology and Metabolism, Imperial College London, London, UK.
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of beta cell function. Here, we show that an lncRNA-transcribed antisense to Pax6, annotated as Pax6os1/PAX6-AS1, was upregulated by high glucose concentrations in human as well as murine beta cell lines and islets. Elevated expression was also observed in islets from mice on a high-fat diet and patients with type 2 diabetes.
View Article and Find Full Text PDFComparative analysis of the whole transcriptome landscapes of muscle and adipose tissue in Qinchuan beef cattle.
BMC Genomics
January 2025
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Background: Muscle and adipose tissue are the most critical indicators of beef quality, and their development and function are regulated by noncoding RNAs (ncRNAs). However, the differential regulatory mechanisms of ncRNAs in muscle and adipose tissue remain unclear.
Results: In this study, 2,343 differentially expressed mRNAs (DEMs), 235 differentially expressed lncRNAs (DELs), 95 differentially expressed circRNAs (DECs) and 54 differentially expressed miRNAs (DEmiRs) were identified in longissimus dorsi muscle (LD), subcutaneous fat (SF) and perirenal fat (VF) in Qinchuan beef cattle.
ECGEFNet: A two-branch deep learning model for calculating left ventricular ejection fraction using electrocardiogram.
Artif Intell Med
January 2025
Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, China; Clinical Medical Research Center of Imaging in Liaoning Province, Shenyang, China.
Left ventricular systolic dysfunction (LVSD) and its severity are correlated with the prognosis of cardiovascular diseases. Early detection and monitoring of LVSD are of utmost importance. Left ventricular ejection fraction (LVEF) is an essential indicator for evaluating left ventricular function in clinical practice, the current echocardiography-based evaluation method is not avaliable in primary care and difficult to achieve real-time monitoring capabilities for cardiac dysfunction.
View Article and Find Full Text PDFL. is an aromatic spice, utilized as an original and peculiar flavoring ingredient in a variety of culinary applications and pharmaceuticals. Black seed ( L.
View Article and Find Full Text PDFYogurt Supplementation Can Ameliorate Fatty Liver Diseases and Metabolic Syndrome in High Fat-Induced Conditions in Mice.
Food Sci Nutr
January 2025
Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences Ibn Zohr University Agadir Morocco.
Hepatic steatosis/non-alcoholic fatty liver disease is a major public health delinquent caused by the excess deposition of lipid into lipid droplets (LDs) as well as metabolic dysregulation. Hepatic cells buildup with more fat molecules when a person takes high fat diet that is excessive than the body can handle. At present, millions of people in the world are affected by this problem.
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