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Late gestation heat stress alters O regulation in placenta and neonatal heifers.
Placenta
January 2025
Department of Animal Sciences, University of Florida, Gainesville, USA. Electronic address:
Introduction: Maternal hyperthermia (i.e. heat stress) can adversely affect placental development and function, with severity varying based on pregnancy stage.
View Article and Find Full Text PDFHuman Brain Organoids Model Abnormal Prenatal Neural Development Induced by Thermal Stimulation.
Cell Prolif
December 2024
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Department of Neurology, Affiliated Zhongda Hospital, Southeast University, Nanjing, China.
The developing human foetal brain is sensitive to thermal stimulation during pregnancy. However, the mechanisms by which heat exposure affects human foetal brain development remain unclear, largely due to the lack of appropriate research models for studying thermal stimulation. To address this, we have developed a periodic heating model based on brain organoids derived from human pluripotent stem cells.
View Article and Find Full Text PDFCase Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery.
A A Pract
December 2024
From the Department of Anesthesiology, Uniformed Services University, Bethesda, Maryland.
Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics.
View Article and Find Full Text PDFIntrauterine fetal growth restriction in sheep leads to sexually dimorphic programming of Preadipocytes' differentiation potential.
Physiol Rep
December 2024
Departmet of Physiology, University of Arizona, Tucson, Arizona, USA.
Fetal growth restriction (FGR) is a risk factor for obesity in adult life. Importantly, growth-restricted females are more prone to obesity than males. The mechanisms involved in this sexually dimorphic programming are not known.
View Article and Find Full Text PDFImmediate Care for Common Conditions in Term and Preterm Neonates: The Evidence.
Neonatology
November 2024
Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Background: Several interventions provided to newborns at birth or within 24 h after birth have been proven critical in improving neonatal survival and other birth outcomes. We aimed to provide an update on the effectiveness and safety of these interventions in low- and middle-income countries (LMICs).
Summary: Following a comprehensive scoping of the literature, we updated or re-analyzed the LMIC-specific evidence for included topics.
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