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http://dx.doi.org/10.1016/s0140-6736(72)91108-7DOI Listing

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Article Synopsis
  • The study investigates how endotoxemia, a pro-inflammatory response from gut bacteria entering the bloodstream, affects cognitive functions in healthy adults, particularly focusing on working memory improvement over time.
  • Conducted with 162 participants aged 25-65, the research involved measuring endotoxemia levels and evaluating cognitive performance at three points over nine months.
  • Results indicated that lower endotoxemia predicted better working memory enhancement, but interestingly, men with higher endotoxemia had better overall working memory performance, while women's performance remained consistent regardless of endotoxemia levels.
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Article Synopsis
  • The study investigates how the physical state of dietary fats (liquid vs. solid) affects inflammation and endotoxin levels in healthy men after consuming high-fat meals.
  • Fourteen participants consumed emulsions of palm stearin oil with different lipid states, and blood samples were taken at various times after each meal.
  • The results showed no significant differences in inflammatory markers between the lipid states, although some baseline characteristics of participants influenced responses, implying that lipid crystallinity does not have a major impact on short-term inflammation.
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Sugar beverages are discussed as critical in the development of metabolic endotoxemia. Here, employing a cross-over design study we assessed the effect of diluted cloudy apple juice (AJ), an iso-caloric and -sweetened placebo (P), or water (W) on post-prandial endotoxemia in healthy, normal weight adults. After obtaining fasting blood, 19 healthy men and women consumed 500 mL AJ, P, or W in a randomized order and blood was taken 120 and 180 min later.

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Article Synopsis
  • Women with polycystic ovary syndrome (PCOS) face increased cardiovascular risks and chronic inflammation due to factors like obesity and gut microbiota interactions.
  • The study analyzed the impact of macronutrients (glucose, lipids, protein) on intestinal permeability by measuring specific biomarkers among women with PCOS, non-hyperandrogenic women, and men.
  • Results showed that obesity heightened certain gut barrier dysfunction markers, and women with PCOS had worsened post-meal responses related to intestinal permeability, indicating interactions between obesity and PCOS affect gut health.
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: Interesterification is an industrial processing technique used widely where hard fats are essential for functionality and consumer acceptability, margarines and lower fat spreads. : The aim of this study was to compare acute cardiovascular effects of functionally equivalent spreads (similar solid fat content) made with interesterified (IE) or non-IE palm-based fats, or spreadable butter. : A randomised, controlled, 4-armed crossover, double-blind study (25 men, 25 women; 35-75 years; healthy; mean BMI 24.

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