Characteristics of functional organization and autoregulation of natural polysubstrate digestion in various animals are largely defined by regulatory properties of the enzymes ensuring membrane digestion. This has been demonstrated for both the animals which are at different evolutional levels and those specialized for different types of food. The effective organization of the digestive and transport processes in time and space is provided by an interaction of food substances at the stage of membrane digestion.
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Cell Host Microbe
January 2025
The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; UCD School of Medicine, University College Dublin, Dublin, Ireland. Electronic address:
Intestinal fibrosis associated with Crohn's disease is a serious yet poorly understood clinical complication. In this issue of Cell Host & Microbe, Ahn and colleagues provide evidence that the adherent intestinal E. coli produced the metallophore yersiniabactin, which sequesters zinc to drive intestinal fibrosis in a HIF-1α-dependent manner.
View Article and Find Full Text PDFCell Host Microbe
January 2025
Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:
Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Key Laboratory of Molecular Nanostructure and Nanotechnology, Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and responsible molecules of such local bacteria-tumor direct interaction on cancer therapeutic response remain poorly understood. Trastuzumab is among the most commonly used drugs targeting the receptor tyrosine-protein kinase erbB-2 (ErbB2) in breast cancer, but its resistance is inevitable, severely limiting its clinical effectiveness.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC-targeted nanoplatform that integrates bimetallic FeMoO nanoparticles with CO-releasing molecules, and further camouflaged with SP94 peptide-modified macrophage membrane for enhanced ferroptosis-driven multi-modal therapy of HCC. Leveraging the multi-enzyme activities of the multivalent metallic elements, the nanoplatform not only decomposes HO to generate oxygen and alleviate tumor hypoxia but also depletes glutathione to inactivate glutathione peroxides 4, which amplify sonodynamic therapy and ferroptotic tumor death under ultrasound (US) irradiation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Faculty of Medicine, Arish University, Arish, North Sinai, Egypt.
Background: Lingual taste cells (LTCs) are taste buds' sensory cells that modulate gustation. This study's aim is to assess whether it can be successfully implanted in hippocampus, modulating learning and memory deficits observed in Alzheimer's Dementia (AD).
Methods: Retrospective trials on rodents i.
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