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Efficacy and safety of tyrosine kinase inhibitors with thoracic radiotherapy for patients with oncogene-mutated non-small cell lung cancer: a meta-analysis.
Radiat Oncol
November 2024
Department of Oncology, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, 3 Kangxin Road, Zhongshan, 528400, Guangdong, China.
Background: Tyrosine Kinase Inhibitors (TKIs) is an important therapy for patients with oncogene-mutated Non-Small Cell Lung Cancer (NSCLC). However, acquired resistance remains a major challenge. The efficacy of TKIs plus thoracic radiotherapy (RT) in oncogene-mutated NSCLC patients is uncertain.
View Article and Find Full Text PDFA Million Person Study Innovation: Evaluating Cognitive Impairment and other Morbidity Outcomes from Chronic Radiation Exposure Through Linkages with the Centers for Medicaid and Medicare Services Assessment and Claims Data.
Radiat Res
December 2024
National Council on Radiation Protection and Measurements, Bethesda, Maryland.
Article Synopsis
- The Million Person Study (MPS) investigates the health impacts of gradual exposure to ionizing radiation on over one million U.S. radiation workers and veterans, focusing on both cancer and non-cancer conditions.
- Recent efforts have highlighted mortality patterns related to neurological and behavioral disorders, such as Parkinson's and Alzheimer's diseases, by analyzing claims data from Medicare beneficiaries.
- To manage the extensive and complex dataset, the MPS is developing specialized open-source software (Colossus) to facilitate detailed evaluation of health outcomes and related factors from the collected health information.
Letter to editor regarding "bone modifying agents in breast cancer patients as adjuvant therapy and prevention of cancer treatment-induced bone loss (CTIBL): Evaluation of risk of medication-related osteonecrosis of the jaw (MRONJ)".
Support Care Cancer
October 2024
Department of Medicine, Oncology Unit, "SS Antonio E Biagio E C. Arrigo" Hospital, 15121, Alessandria, Italy.
Expression, Purification, and Anti-UV Irradiation Effect of RsSOD on HCE-T Human Corneal Epithelial Cells.
Genes (Basel)
August 2024
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Superoxide dismutase (SOD) is a class of enzymes that catalyze the disproportionation of superoxide anion radicals into hydrogen peroxide and oxygen. It can remove excessive free radicals in organisms and acts as a potent antioxidant, cleaning free radicals generated by radiation and protecting cells from oxidative damage. In this study, we obtained a MnSOD gene from the radiation-resistant bacterium sp.
View Article and Find Full Text PDFAmerican Radium Society Appropriate Use Criteria on Cardiac Toxicity Prevention and Management After Thoracic Radiotherapy.
J Thorac Oncol
December 2024
New York Proton Center, New York, New York.
Introduction: The multidisciplinary American Radium Society Thoracic Committee was assigned to create appropriate use criteria on cardiac toxicity prevention and management for patients undergoing radiotherapy.
Methods: A systematic review of the current literature was conducted. Case variants of patients with thoracic malignancies undergoing radiation were created based on presence or absence of cardiovascular risk factors and treatment-related risks assessed by dose exposure to the heart and cardiac substructures.
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