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Post-traumatic stress disorder symptoms and associated factors in newly diagnosed breast cancer survivors: A cross-sectional study.
Eur J Oncol Nurs
January 2025
West China School of Nursing/West China Hospital, Sichuan University, 37 Guoxue Xiang Street, Chengdu, 610041, Sichuan Province, China. Electronic address:
Purpose: The research aimed to investigate the prevalence of PTSD in newly diagnosed Chinese women with breast cancer and to distinguish a munber of sociodemographic, disease-related and psychosocial factors connected with the severity of PTSD symptom.
Methods: This cross-sectional study recruited 674 newly diagnosed Chinese women with breast cancer at three tertiary level a general hospitals in Chengdu, China between August 2022 and May 2023. And questionnaires about general information, locus of control, social support, coping styles, emotional regulation and PTSD were filled out.
Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome- paving the path towards precision medicine: a case report.
J Cancer Res Clin Oncol
January 2025
Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.
Background: Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome characterized by a high familial incidence of various malignancies. It results from pathogenic/likely pathogenic heterozygous constitutional variants of the TP53 gene. Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible to mitigate the high incidence of treatment-related secondary malignancies in these patients.
View Article and Find Full Text PDFThe influence of locus of control, coping strategies and time perspective on post-traumatic growth in survivors with primary breast cancer.
BMC Psychol
January 2025
Pôle de Psychologie Sociale (PôPS), Unité Inserm U1296 Radiations : Défense, Santé, Environnement, Université Lyon 2, Bron, France.
Background: Breast cancer, a potential traumatic stressor, may be accompanied by positive changes, such as post-traumatic growth (PTG), which may allow patients to overcome this stressful event more easily. Our aim was to identify factors associated with PTG in breast cancer survivors (BCSs).
Methods: We conducted a cross-sectional study in Seintinelles volunteers who answered online questionnaires.
Swedish Genome-Wide Haplotype Association Analysis Suggests Breast Cancer Loci with Varying Risk-Modifying Effects.
Genes (Basel)
December 2024
Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.
To find support for risk-modifying genes in breast cancer, a haplotype GWAS in sporadic breast cancer cases was undertaken. The results were compared with the results from previous analyses in familial cases and all cases from the same Swedish cohort. In total, 2550 women with sporadic invasive breast cancer and 5021 healthy controls were included in a sliding-window haplotype GWAS using PLINK 1.
View Article and Find Full Text PDFExtract and Its Active Metabolite α-Cyperone Alleviates Paclitaxel-Induced Neuropathic Pain via the Modulation of the Norepinephrine Pathway.
Metabolites
December 2024
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.
Background: Paclitaxel is a widely used anticancer drug for ovarian, lung, breast, and stomach cancers; however, its clinical use is often limited by the side effects of peripheral neuropathy. This study evaluated the effects of () extract and its active metabolite, α-cyperone, on paclitaxel-induced neuropathic pain.
Methods: The oral administration of extract at doses of 500 mg/kg and intraperitoneal administration of α-cyperone at doses of 480 and 800 μg/kg prevented both the development of cold and mechanical pain.
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