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Intraoperative Use of Sodium Bicarbonate Ringer's Solution Instead of Sodium Lactate Ringer's Solution to Reduce Endothelial Glycocalyx Degradation and Improve Postoperative Recovery During Cardiopulmonary Bypass Cardiac Surgery: A Single-Center Prospective Cohort Study.
Drug Des Devel Ther
December 2024
Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People's Republic of China.
Objective: To investigate the effect of sodium bicarbonate Ringer's solution (BRS) on the degradation of endothelial glycocalyx components in patients undergoing cardiopulmonary bypass (CPB) during cardiac surgery, and to evaluate its impact on endothelial glycocalyx preservation and postoperative recovery.
Patients And Methods: A total of eight patients scheduled for elective CPB heart surgery were included and randomly divided into two groups: the sodium lactate Ringer's solution (LRS) group and the BRS group. ELISA was used to measure plasma concentrations of syndecan-1, matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-3 (MMP-3), IL-6, IL-8, TNF-α, and TGF-β at predefined time points: T0 (before induction of anesthesia), T3 (immediately after weaning from CPB), T5 and T6 (24 and 72 hours postoperatively).
Effects of autophagy on the selective death of human breast cancer cells exposed to plasma-activated Ringer's lactate solution.
Free Radic Res
November 2024
Department of Electronics, Graduate School of Engineering, Nagoya University, Nagoya, Japan.
Article Synopsis
- Plasma-activated Ringer's lactate (PAL) is being explored as a cancer therapy with no known side effects, but it has been found to trigger autophagy, which may undermine its antitumor effects.
- Research revealed that this autophagy can temporarily aid in the proliferation of MCF-7 human breast cancer cells upon exposure to PAL solution.
- The study identified specific compounds in PAL, like acetate and 2,3-dimethyltartrate, that promote autophagy, and noted that 2,3-dimethyltartrate can either cause cell death or trigger autophagy depending on its concentration.
Micro/Nanobubble-Assisted Lipotransfer: In Vivo Evidence of Improved Graft Outcomes.
Ann Plast Surg
December 2024
From the Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, Orange, CA.
Objective: Retention rates of lipotransfer remain variable, with the underlying cause associated with tissue oxygenation and blood supply barriers. One promising new method of improving tissue oxygenation is micro/nanobubbles (MNBs), which are small gas bubbles (<100 μm) generated within a saline solution. MNBs are stable and carry a significant amount of oxygen, and because of their negatively charged surface characteristics, they are an ideal oxygen-delivery solution.
View Article and Find Full Text PDFFluid management of acute kidney injury.
Curr Opin Crit Care
December 2024
Department of Anaesthesia and Intensive Care Medicine, University Hospital Galway.
Purpose Of Review: Acute kidney injury (AKI) is commonly encountered in critical care medicine as is intravenous fluid therapy. It is accepted that there is interplay between fluid use and AKI, both potentially positive and negative. An understanding of the physiological rationale for fluid is important to help clinicians when considering fluid therapy in patients with, or at risk for AKI; this includes understanding choice of fluid, method of monitoring, administration and clinical sequelae.
View Article and Find Full Text PDFCold atmospheric plasma-activated saline alleviates secondary injury post-SCI by inhibiting extracellular matrix remodeling and infiltration of proinflammatory macrophages.
Exp Neurol
January 2025
Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address:
Article Synopsis
- CAP-activated saline (CAP-AS) treatment improves recovery and motor function in mice with spinal cord injuries compared to untreated controls.
- Transcriptome analysis reveals that CAP-AS affects gene expression related to extracellular matrix and immune response, suggesting mechanisms behind its protective effects.
- Treatment with CAP-AS reduces inflammation, decreases macrophage infiltration, and promotes tissue healing, as seen through various histological and cytokine assessments.
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