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Drug-Induced Liver Injury-Pharmacological Spectrum Among Children.
Int J Mol Sci
February 2025
2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Drug-induced liver injury (DILI) is one of the main causes of acute liver failure in children. Its incidence is probably underestimated, as specific diagnostic tools are currently lacking. Over 1000 known drugs cause DILI, and the list is expanding.
View Article and Find Full Text PDFSimvastatin Enhances the Cytotoxic Effects of Doxorubicin in a Mammary Adenocarcinoma Cell Model by Involving Connexin 43.
J Biochem Mol Toxicol
March 2025
Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.
Gap Junctions channels formed by Connexins (Cx) provide intercellular communication enabling the coordination of cell growth, differentiation, and metabolism, and their reduction has been shown in many tumor types. Expression levels of Cx43, the most extensively studied Gap Junctions forming protein, are reduced or completely absent in breast cancer cells, while their overexpression correlates with increased cellular permeability to anticancer agents and, consequently, reduced resistance to drug treatments. So, drug associations targeting Cx43 are being considered to overcome chemoresistance.
View Article and Find Full Text PDFStreptozotocin-induced hyperglycemia unmasks cardiotoxicity induced by doxorubicin.
Sci Rep
March 2025
Inserm UMR-S 942 MASCOT, University of Paris Cité, Lariboisière Hospital, Paris, France.
Late-onset cardiotoxicity induced by anthracyclines occurs years to decades after completion of anti-cancer therapy and is associated with increased morbi-mortality of cancer survivors. Chemotherapy at the time of treatment probably causes cardiac damages for which the juvenile heart compensate. Co-morbidities happening in the adulthood such as type 1 diabetes (DT1), affect the heart and thus can unmask chemotherapy induced cardiotoxicity.
View Article and Find Full Text PDFPHD-2/HIF-1α axis mediates doxorubicin-induced angiogenesis in SH-SY5Y neuroblastoma microenvironment: a potential survival mechanism.
Sci Rep
March 2025
Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Giza, 12578, Egypt.
The response of neuroblastoma (NB) cells to chemotherapeutics and their influence on NB microenvironment remain incompletely understood. Herein, we examined the underlying molecular mechanism via which Doxorubicin, a chemotherapeutic agent used for NB treatment, promotes proangiogenic response in the SH-SY5Y microenvironment. Doxorubicin treatment at 1 µg/ml reduced SH-SY5Y cell proliferation and primed the apoptosis pathway.
View Article and Find Full Text PDFAcute Generalized Exanthematous Pustulosis in a 76-year-Old Man With Neuroendocrine Carcinoma of the Lung, Responsive to Ixekizumab.
Clin Cosmet Investig Dermatol
February 2025
Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People's Republic of China.
Acute generalized exanthematous pustulosis (AGEP) is a rare, painful, and pruritic drug-induced rash characterized by sterile pustules on an erythematous base, followed by desquamation. While commonly induced by antibiotics, cases associated with antineoplastic drugs have become more frequent in recent years. Here, we report a 76-year-old Chinese male with lung large-cell neuroendocrine carcinoma who developed erythema and pustules on his left lower leg, which spread to the trunk and limbs after the fourth cycle of immunotherapy and chemotherapy.
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