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Clinical Outcome of Endothelium-Outward Preloaded Descemet Membrane Endothelial Keratoplasty in Long-Term Dextran-Containing Transport Medium Preservation.
Cornea
January 2025
Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach/Saar, Germany.
Purpose: To analyze the clinical outcome of organ-cultured endothelium-outward preloaded DMEK (pDMEK) using the RAPID cartridge.
Methods: This prospective study included 80 eyes of 80 patients who received a pDMEK. Best-corrected visual acuity (BCVA), endothelial cell count (ECC), and central corneal thickness were measured preoperatively and 4 to 6 weeks, 3 months, 6 months, and 1 year postoperatively.
Smart release injectable hydrogel co-loaded with liposomal combretastatin A4 and doxorubicin nanogel for local combinational drug delivery: A preclinical study.
Int J Pharm
January 2025
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Surgical resection and postoperative adjuvant chemotherapy have enhanced the outlook for breast cancer patients. However, tumor relapse and serious side effects of chemotherapy continue to impact patients' quality of life. Designing injectable composite hydrogel made of biodegradable polymers providing sustained release of antiangiogenic and chemotherapeutic agents might play a vital role in elimination of cancer cells.
View Article and Find Full Text PDFBiodegradable exosome-engineered hydrogels for the prevention of peritoneal adhesions via anti-oxidation and anti-inflammation.
Mater Today Bio
December 2024
Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan, 063210, China.
Peritoneal adhesions (PA) are a common and severe complication after abdominal surgery, impacting millions of patients worldwide. The use of anti-adhesion materials as physical barriers is an effective strategy to prevent postoperative adhesions. However, the local inflammatory microenvironment exerts a significant impact on the efficacy of anti-adhesion therapies.
View Article and Find Full Text PDFChanges in Cx43 and AQP4 Proteins, and the Capture of 3 kDa Dextran in Subpial Astrocytes of the Rat Medial Prefrontal Cortex after Both Sham Surgery and Sciatic Nerve Injury.
Int J Mol Sci
October 2024
Cellular and Molecular Neurobiology Research Group, Department of Anatomy, Faculty of Medicine, Masaryk University, CZ-62500 Brno, Czech Republic.
Article Synopsis
- Subpial astrocytes, part of the brain's surface interface known as the "glia limitans superficialis" (GLS), play a key role between brain tissue and cerebrospinal fluid.
- The study investigated changes in the proteins connexin-43 (Cx43) and aquaporin-4 (AQP4) in these astrocytes after surgeries involving sciatic nerve compression (SNC). Results showed increased Cx43 levels but decreased AQP4 levels, affecting their function.
- Findings indicate that both nerve injuries (SNC) and non-injurious operations can cause significant alterations in subpial astrocyte activity, resulting in impaired water and solute uptake despite enhanced connectivity
Endoscopic injection vs anti-reflux surgery for moderate- and high-grade vesicoureteral reflux in children: a cost-effectiveness international study.
J Robot Surg
October 2024
Service de Chirurgie Pédiatrique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Article Synopsis
- The study examines the effectiveness of endoscopic injections versus ureteral reimplantation for treating vesicoureteral reflux (VUR) in children with grades III, IV, and V, using data from 400 patients over a follow-up period of at least 5 years.
- In Group A (endoscopic injections), patients experienced shorter surgery times, less need for pain relief, shorter hospital stays, and lower costs, but faced higher rates of post-procedure complications and redo surgeries compared to Group B (surgery).
- Overall, while endoscopic treatment is quicker and cheaper with certain advantages, the surgical approach has a lower recurrence rate, suggesting potential long-term benefits for children.
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