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Influence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses.
Nutrients
December 2024
Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Background/objectives: Stimulated cord blood mononuclear cell (CBMC) cytokine responses were previously shown to predict the risk of childhood atopic disease. Iron deficiency (ID) at birth may also program atopic disease. Males are at a higher risk of pediatric atopic disease, but it is not known whether congenital ID impacts CBMC immune responses differentially by sex.
View Article and Find Full Text PDFAspartame subacute exposure does not affect immune system of BALB/c mice following a tiered approach.
Tissue Cell
December 2024
Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran. Electronic address:
Background: The objective of the present study was to assess potential immunotoxic effects of aspartame in BALB/c mice.
Methods: Aspartame was administered orally at 400 and 2000 mg/kg for two weeks (five days per week). Specific parameters of humoral and cellular immune responses including hemagglutinating antibody (HA) titer, cytokine production (IFN-γ and IL-4 levels), delayed type hypersensitivity (DTH) response to SRBCs, histopathological examination of spleen and bone marrow, and T-lymphocyte proliferation in response to phytohemagglutinin-A (PHA) were evaluated.
The T cell response to SARS-CoV-2 mRNA vaccine in adults with high exposure to perfluoroalkyl substances from Ronneby, Sweden.
Chemosphere
December 2024
School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Box 414, 405 30, Gothenburg, Sweden.
Background: Perfluoroalkyl substances (PFAS) have been associated with impaired antibody levels after childhood vaccinations and immunosuppressive effects in animals. However, the in vivo effects of PFAS on antigen specific human T cell responses have not been investigated in adults. In Ronneby, Sweden, the drinking water of one of the water works was previously highly contaminated with primarily perfluorohexane sulfonic acid (PFHxS) and perfluorooctane sulfonic acid (PFOS).
View Article and Find Full Text PDFProtein Kinase C Isozyme Immaturity/Deficiency in Cord Blood Monocytes and Neutrophils.
Int J Mol Sci
October 2024
Department of Immunopathology, SA Pathology at the Women's and Children's Hospital, North Adelaide, SA 5006, Australia.
Article Synopsis
- Reduced levels of Protein Kinase C (PKC)ζ in cord blood T cells are linked to the development of allergies in children and a tendency to favor an immature T-helper (Th)2 cytokine response.* -
- Cord blood monocytes and neutrophils also exhibit low levels of various PKC isozymes compared to adult blood, indicating a broader deficiency in these immune cells.* -
- While PKCζ levels in cord blood T cells correlate with those in monocytes, this does not influence the differentiation of the T cells towards Th1 or Th2 cytokine profiles, unlike in T cells.*
Recommended or high daily intakes of plant stanol esters do not affect T-cell derived cytokine production in immunologically healthy volunteers.
Br J Nutr
October 2024
Department of Nutrition and Movement Sciences, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
A well-functioning immune system requires balanced immune responses. studies have shown that plant stanols contribute to restoring the T-helper (Th)1/Th2 ratio when it is imbalanced. However, effects of plant stanols on healthy immune responses are unknown.
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