Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0447.1971.tb02142.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effectiveness of a 40-year long iodine prophylaxis in endemic goitre region of Grobnik, Croatia.
Coll Antropol
December 2005
Department of Internal Medicine, University Hospital Center "Rijeka", School of Medicine Rijeka, Rijeka, Croatia.
The region of Grobnik, in the north west of Croatia, 15 km away from the Adriatic coast and 400 meters above the sea level, used to be known as a centre of endemic goitre. Iodine prophylaxis of 10 mg KJ added per kilo salt started in Croatia during the year 1953 and it was increased to 25 mg KJ per kilo in 1996. During 1961, the prevalence of goitre among Grobnik school children was 63%, while in the adult population it was 34%.
View Article and Find Full Text PDFA nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger.
J Clin Endocrinol Metab
July 1993
Cátedra de Genética y Biología Molecular, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina.
Defective or impaired thyroglobulin (Tg) synthesis usually results in congenital goitrous hypothyroidism, virtual absence of Tg in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis. We have previously reported two siblings with this syndrome that was attributable to decreased levels of thyroid tissue Tg mRNA, resulting in decreased translation of a fully mature Tg.
View Article and Find Full Text PDFDefective organification of iodide causing hereditary goitrous hypothyroidism.
Thyroid
October 1993
Division of Endocrinology, Hospital das Clínicas, University of Sao Paulo Medical School, Brazil.
We present a survey of the current state of knowledge about the prevalence of the syndrome involved in defective organification of iodide, and the mechanism of iodination and coupling catalyzed by the thyroid peroxidase (TPO) enzyme. A brief summary of the recent developments in molecular cloning of TPO and regulation of TPO gene expression is also included. Methods for purification of the enzyme and details about the assessment of TPO activity in tissue are briefly explained.
View Article and Find Full Text PDFHereditary congenital goitre with thyroglobulin deficiency causing hypothyroidism.
Clin Endocrinol (Oxf)
June 1984
The thyroid glands of two hypothyroid goitrous siblings aged 13 and 14 and of a 21-year-old hypothyroid goitrous female were examined. In all three patients a very high thyroid uptake of iodide was observed in the presence of a negative perchlorate discharge test. An abnormally high serum protein bound iodine (12.
View Article and Find Full Text PDFWe have studied hereditary congenital goiter in an inbred strain of goats. On a normal diet, the goats were hypothyroid and iodide taken up by the gland was released rapidly in the form of iodinated macromolecular material. This resulted in a low thyroidal iodine pool.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!