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The role of gluten in multiple sclerosis: A systematic review.

Mult Scler Relat Disord

January 2019

Multiple Sclerosis Clinic, Department of Neurology, Rigshospitalet Glostrup and University of Copenhagen, Valdemar Hansens Vej 13, DK-2600 Denmark. Electronic address:

Background: There is an increasing interest in diet as a modifying factor in multiple sclerosis (MS), and gluten has been suggested to affect MS.

Objective: The aim of this systematic review is to qualitatively evaluate the evidence on the role of gluten in MS.

Methods: A review protocol was submitted to PROSPERO.

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Introduction: Elevated serum interleukin (IL) 6 has been reported in patients infected with the hepatitis C virus (HCV), but it remains debatable whether this influences the production of autoantibodies and the biochemical profile of HCV disease. Therefore, this current study was conducted to evaluate the relationship between IL-6 and circulating autoantibody levels in HCV positive patients. Methods: Levels of IL-6 in serum samples from 102 patients with HCV and 103 normal controls were determined by enzyme linked immunosorbent assay (ELISA).

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Aim Of The Study: The aim of the present study was to define the frequency of organ-specific and non-organ-specific autoantibodies in a cohort of Latent Autoimmune Diabetes in Adults (LADA) patients and to test whether multiple antibodies positivity could be a predictor of early insulin dependence.

Materials And Methods: We enrolled 210 LADA and 210 type 2 diabetes mellitus (T2D) patients. In all subjects anti-islet antigen-2 (IA-2Ab), anti-thyroperoxidase (TPOAb), anti-zinc transporter 8 (ZnT8Ab), anti-nuclear (ANA), anti-parietal cell (APCA), anti-smooth muscle (ASMA), anti-mitochondrial (AMA), anti-liver kidney microsomes (LKM), and anti-reticulin (ARA) circulating antibodies were assessed.

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Background: Psoriasis is a common, chronic, disfiguring, inflammatory and proliferative condition of skin manifested by red, scaly, sharply demarcated, indurated plaques present particularly over the extensor surfaces and scalp. The disease has been found to be associated with celiac disease related antibodies with variable frequencies in different populations of the world. The subset of patients showing this association have a higher psoriasis severity and also respond well to cost effective way of gluten free diet.

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