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Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy.
Mater Today Bio
February 2025
Department of Nuclear Medicine, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, 730050, China.
Liposomal nanocarriers are able to carry peptides for efficient and selective delivery of radioactive tracer and drugs into the tumors. Angiopoietin 2 (ANGPT2) is an excellent biomarker for precise diagnosis and therapy of glioma. The present study aimed to design ANGPT2-specific peptides to modify the surface of nanoliposomes containing doxorubicin (Dox) for integrative imaging and targeting therapy of glioma.
View Article and Find Full Text PDFTime-lag effects of NEP and NPP to meteorological factors in the source regions of the Yangtze and Yellow Rivers.
Front Plant Sci
January 2025
Yellow River Institute of Hydraulic Research, Henan Key Laboratory of Yellow Basin Ecological Protection and Restoration, Zhengzhou, China.
Vegetation productivity and ecosystem carbon sink capacity are significantly influenced by seasonal weather patterns. The time lags between changes in these patterns and ecosystem (including vegetation) responses is a critical aspect in vegetation-climate and ecosystem-climate interactions. These lags can vary considerably due to the spatial heterogeneity of vegetation and ecosystems.
View Article and Find Full Text PDFTale of Three Dithienylethenes: Following the Photocycloreversion with Ultrafast Spectroscopy and Quantum Dynamics Simulations.
J Phys Chem B
January 2025
Institute of Physics, Lodz University of Technology, ul. Wólczańska 217/221, 93-590 Łódź, Poland.
Photocycloreversion reactions of three diarylethene derivatives whose structures differ only in the placement of two sulfur atoms in the cyclopentene rings are investigated. Despite the minuscule differences between the molecules, both the yields and times of the photoreactions vary considerably. Using UV-vis and infrared femtosecond spectroscopy and quantum chemical dynamics simulations, we elucidate the relationships among the quantum yield, electronic and vibrational relaxation time, and structural properties of the dithienylethene photoswitches.
View Article and Find Full Text PDFRadiation dose assessment and establishment of diagnostic reference levels for MDP Tc-99m bone scans: A multi-hospital study in Saudi Arabia.
Appl Radiat Isot
January 2025
Medical Diagnostic Imaging Department, College of Health Science, University of Sharjah, Sharjah, United Arab Emirates.
Background: Bone scans using technetium-99m methylene diphosphonate (99mTc-MDP) are widely used in nuclear medicine for diagnosing various bone disorders. However, the radiation exposure associated with these procedures necessitates careful consideration and optimization.
Aim: This study aimed to evaluate radiation doses in terms of Effective Dose (ED) and establish Diagnostic Reference Levels (DRLs) for 99mTc-MDP bone scans in Saudi Arabia.
Therapeutic strategies for fungating and ulcerating breast cancers: A systematic review and narrative synthesis.
Breast
December 2024
Radiation Oncology Unit, REM Radioterapia Srl, 95029, Viagrande, Italy; Department of Medicine and Surgery, University of Enna Kore, Enna, Italy. Electronic address:
Background: To identify optimal therapeutic strategies for managing fungating, large or ulcerating breast tumors and highlight existing gaps in the literature.
Methods: We conducted a systematic search of Medline, Embase, APA, PsycInfo, CAB abstracts, Scopus, and Web of Science from inception to June 30, 2024, including studies on patients with fungating, large, or ulcerating breast cancers.
Results: The search identified 7917 studies, with 79 meeting the inclusion criteria: 62 case reports, 7 case series, and 10 cohort studies.
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