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Autoimmune Hepatitis and Systemic Lupus Erythematosus Overlap Syndrome: A Case Report and Literature Review.
Cureus
December 2024
Gastroenterology and Hepatology, Salmaniya Medical Complex, Manama, BHR.
Autoimmune hepatitis-systemic lupus erythematosus (AIH-SLE) overlap syndrome is a rare disease entity. In some cases, a delay in the occurrence of overlap is observed, where the diagnosis of one of the conditions precedes the other. However, other patients have features of both disorders simultaneously upon initial presentation, leading to a direct diagnosis of AIH-SLE overlap syndrome.
View Article and Find Full Text PDFGalectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane.
Sci Rep
October 2019
Programa de Pós-graduação em Ciências Aplicadas a Produtos para Saúde (PPGCAPS), Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Galectin-3 (Gal-3) controls intercellular and cell-extracellular matrix interactions during immunological responses. In chronic inflammation, Gal-3 is associated with fibrotic events, regulates B cell differentiation and delays lupus progression. Gal-3 deficient mice (Lgals3) have intense germinal center formation and atypical plasma cell generation correlated to high levels IgG, IgE, and IgA.
View Article and Find Full Text PDFFamilial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden.
Psychiatr Genet
April 2019
Center for Primary Health Care Research, Lund University, Malmö, Sweden.
Aims: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.
Participants And Methods: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century.
Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis).
Am J Med Sci
April 2017
Department of Internal Medicine, Texas tech University health Sciences Center, Lubbock, Texas. Electronic address:
Liver dysfunction occurs in approximately 50% of patients with systemic lupus erythematosus (SLE), and patients with SLE and elevated liver enzymes can present a complicated and difficult differential diagnosis. Lupus hepatitis and autoimmune hepatitis are 2 immunologic conditions involving the liver, which can have similar clinical, laboratory and systemic presentations, leading to difficulties in diagnosis. Physicians need to be aware of these 2 hepatic diseases as diagnosis and appropriate therapy need to occur early in the disease course to prevent progression to advanced liver disease.
View Article and Find Full Text PDF"Lupoid hepatitis" in SLE patients and mice with experimental lupus.
Clin Immunol
November 2016
Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610. United States. Electronic address:
The unusual subset of patients with severe hepatitis, hypergammaglobulinemia, arthritis, and LE cells in the blood reported by Henry Kunkel and others suggested to these investigators that "lupoid" hepatitis might share pathogenic mechanisms with SLE. More than half a century later, the etiology of autoimmune hepatitis remains unclear. The occurrence of autoimmune hepatitis in a small fraction (about 3%) of SLE patients in our lupus cohort and in two mouse models of SLE supports their conclusion that lupoid hepatitis may be share pathogenic mechanisms with SLE.
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