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Metal Organic Framework Based on Photoactivated Aggregation-Induced Emission Molecule for Achieving Photoexcitation Regulation.
Chem Asian J
January 2025
University of Shanghai for Science and Technology, School of Materials and Chemistry, Shanghai, CHINA.
Ln-MOFs, composed of lanthanide ions and functional organic ligands, are porous materials with tunable structures and unique luminescent properties. However, the interplay between ligand AIE properties and the framework's "antenna effect" on MOF morphology is understudied. Here, Tb-D-Cam-TPTB was synthesized via solvothermal method using TPTB (persulfurated arene) as the primary ligand, D-Cam as the auxiliary ligand, and Tb3+ as the metal ion.
View Article and Find Full Text PDFLysozyme revisited.
Structure
January 2025
Department of Computational Chemistry, Lund University, Chemical Centre, P.O. Box 124, 221 00 Lund, Sweden; European Spallation Source ESS ERIC, P.O. Box 176, 221 00 Lund, Sweden. Electronic address:
Lysozyme is a model system for crystallographers. In this issue of Structure, Ramos et al. report atomic resolution neutron structures of lysozyme, which unambiguously show the protonation states and hydrogen-bonding networks of the active site.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California San Francisco, San Francisco, CA, USA.
Background: The direct and chaperone-associated interactions of E3 ubiquitin ligase CHIP with tau in Alzheimer's disease and other tauopathies, regulates tau turnover, by directly linking it to ubiquitination and proteasomal degradation, as well as through suppression of tau aggregation. Modulation of these CHIP-driven tau clearance mechanisms can be an effective treatment strategy. Antigen-binding antibody fragments (Fabs) are potent tools that can highly-selectively engage target proteins and act as functional probes or inhibitors.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Recent genetic studies have implicated >70 genomic loci associated with the risk for Alzheimer's Disease. However, the underlying functional mechanisms remain unclear. Several functional genomics (FG) methods such as chromosome conformation (CC) capture technologies and expression quantitative trait loci (eQTLs) have been developed to study the genetic targets.
View Article and Find Full Text PDFProteinF3S: boosting enzyme function prediction by fusing protein sequence, structure, and surface.
Brief Bioinform
November 2024
Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, 131 Dong'an Road, 200032 Shanghai, China.
Proteins can be represented in different data forms, including sequence, structure, and surface, each of which has unique advantages and certain limitations. It is promising to fuse the complementary information among them. In this work, we propose a framework called ProteinF3S for enzyme function prediction that fuses the complementary information across protein sequence, structure, and surface.
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