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Negative symptoms of schizophrenia: new developments and unanswered research questions.
Lancet Psychiatry
August 2018
Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Centro de Investigación en Red de Salud Mental, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Negative symptoms of schizophrenia are associated with poor functional outcome and place a substantial burden on people with this disorder, their families, and health-care systems. We summarise the evolution of the conceptualisation of negative symptoms, the most important findings, and the remaining open questions. Several studies have shown that negative symptoms might be primary to schizophrenia or secondary to other factors, and that they cluster in the domains of avolition-apathy and expressive deficit.
View Article and Find Full Text PDFEffect of body-oriented psychological therapy on negative symptoms in schizophrenia: a randomized controlled trial.
Psychol Med
May 2006
Unit for Social & Community Psychiatry, Newham Centre for Mental Health, London, UK.
Background: In order to improve the treatment of medication-resistant negative symptoms in schizophrenia, new interventions are needed. Neuropsychological considerations and older reports in the literature point towards a potential benefit of body-oriented psychological therapy (BPT). This is the first randomized controlled trial specifically designed to test the effectiveness of manualized BPT on negative symptoms in chronic schizophrenia.
View Article and Find Full Text PDFObjective: To provide a more adequate method for integrating our understanding of biological, psychological and social factors in schizophrenia, new concepts and a broader view of scientific method are required. This report aims to describe steps towards these concepts and methods.
Method: Using experiences from a range of research, clinical, and general life encounters, the author reviews assumption about objectivity and science in the mental health field where human experience is a crucial source of data and concepts.
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