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Hemolytic disease of the fetus and newborn and Rhesus alloimmunization in Latin American countries: a scoping review.
BMC Pregnancy Childbirth
December 2024
Immunology LATAM, Janssen, Mendoza, Buenos Aires, CP (1428), 1259, Argentina.
Background: Hemolytic disease of the fetus and newborn (HDFN) is a condition due to maternal blood group antibodies targeting antigens in fetal red blood cells, with significant prenatal/perinatal morbidity and mortality. Severe HDFN cases are often associated with alloimmunization against Rhesus D (RhD) or Kell antigens. Information about HDFN epidemiology and treatment in Latin American countries is limited.
View Article and Find Full Text PDFColombian consensus for the diagnosis, prevention, and management of Rhesus disease.
Rev Colomb Obstet Ginecol
September 2024
Unidad de Medicina Materno Fetal, Clínica Del Prado, Universidad CES. Medellín (Colombia); Fundared Materna. Bogotá (Colombia).
Article Synopsis
- Aiming to standardize care for Rh-D negative pregnant women, a panel of 23 experts developed guidelines focused on prevention and management of Rh isoimmunization and related conditions to improve perinatal outcomes.* -
- Utilizing a modified Delphi method, the panel assessed 22 questions across eight key areas, including Rh-D testing, prenatal care, and treatment strategies for affected fetuses, reaching an 80% consensus on recommendations.* -
- Key recommendations include encouraging preconception consultations for Rh-D negative women, determining maternal Rh-D status during initial healthcare visits, and ascertaining the father's Rh-D status early in prenatal care.*
Neonatal Jaundice: A Study of the Incidence in Children of Rh (D) Negative and 0 Rh (D) Positive Mothers.
Acta Medica (Hradec Kralove)
October 2024
Department of Medical Biophysics, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic.
Despite advances in neonatal care, neonatal jaundice remains a common problem in maternity wards. The present retrospective epidemiological study collected data on a sample of 710 newborns and compared the incidence of neonatal jaundice in infants born to Rh (D) negative and 0 Rh (D) positive mothers. The primary aim was to determine whether the higher incidence of maternal alloimmunisation in newborns was causally related to a potentially higher incidence of neonatal jaundice in newborns of 0 Rh (D) positive mothers.
View Article and Find Full Text PDFRh sensitization in abortion care: where we've been and where we're going.
Curr Opin Obstet Gynecol
December 2024
Stanford University, Palo Alto, California, USA.
Article Synopsis
- The review discusses the historical context and recent research about preventing Rh-alloimmunization during abortion care.
- Recent findings indicate that the risk of Rh-alloimmunization during first trimester abortions is very low.
- High-quality studies show fetal red blood cells can enter maternal circulation before abortion, questioning the necessity of Rh immunoglobulin before 12 weeks of gestation and highlighting the lack of consensus on guidelines for prevention.
Article Synopsis
- This update gives new advice about testing for Rh blood type and giving medicine to people who have an abortion or lose a pregnancy before 12 weeks.
- It changes earlier guidelines from different years about how to handle these situations.
- The goal is to make sure people get the best care during these difficult times.
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